Activation and clonal expansion of autoreactive lymphocytes is a critical step in the pathogenesis of autoimmune diseases. In experimental models of autoimmunity, disease can be transferred by activated, but not resting, autoreactive T cells (1), indicating that activation of autoreactive T cells is required for the development of autoimmune diseases. Infectious agents have long been considered...

This monograph provides an overview of the mathematical theories and computational algorithm design for contagion source detection in large networks. By leveraging network centrality as a tool statistical inference, we can accurately identify contagions, trace their spread, predict future trajectories. approach fundamental insights into surveillance capability asymptotic behavior spreading Math...

Mathematical model-based statistical inference applied to within-host dynamics of infectious diseases can help dissect complex interactions between hosts and microbes. This work has applied advances in model-based inference to understand colonization of cattle by enterohaemorrhagic Escherichia coli O157 : H7 at the terminal rectum. A mathematical model was developed based on niche replication a...

We present a new mathematical framework for exploring the ecological and immunological interactions between multiple infectious diseases. The mechanism underlying the ecological interaction is the modulation of susceptible numbers for one pathogen as a result of quarantining or mortality following infection with a competitor. Immunological interactions are assumed to result from immunosuppressi...

For many cancer types, incidence rises rapidly with age as an apparent power law, supporting the idea that cancer is caused by a gradual accumulation of genetic mutations. Similarly, the incidence of many infectious diseases strongly increases with age. Here, combining data from immunology and epidemiology, we show that many of these dramatic age-related increases in incidence can be modeled ba...

There are different bovine infectious diseases that show economic losses and social problems in various sectors of the economy. Most studies focused on some (for example, tuberculosis, salmonellosis, brucellosis), but there few other which not officially controlled also have an impact This work is a systematic literature review models (as theoretical scheme, generally mathematical form) used ep...