Therapy for congenital ichthyoses remains unsatisfactory. Ichthyoses, characterized by barrier impairment with cutaneous erythema and scaling, share Th17 immune skewing, as in psoriasis, leading us to hypothesize that targeting IL-17A could reduce ichthyosis severity. Adults were randomized 1:1 receive 300 mg of secukinumab, an inhibitor, or placebo every 4 wks a 16-wk dual-center, double-blind...

Congenital ichthyoses (CI), inherited scaling disorders, have an impaired epidermal barrier, but ceramide (Cer) changes are poorly understood. Using untargeted lipidomics, we compared Cer profiles of tape-stripped skin from 77 patients with 6 subtypes CI and 19 matched controls. In CI, 636 species were found, including 24 low-abundance Cers not in healthy skin. 221 significantly (>2-fold; adj. ...

Videodermoscopy of hair and scalp (trichoscopy) is gaining popularity as a valuable tool in differential diagnosis of hair loss. This method allows viewing of the hair and scalp at X20 to X160 magnifications. Structures which may be visualized by trichoscopy include hair shafts of different types: vellus, terminal, micro-exclamation mark type, monilethrix, Netherton type, and pili annulati hair...