Traditional chemotherapeutic drugs are often restricted by severe side effects and lack of tumor specificity. Peptide prodrugs cleavable by peptidases present in the tumor environment have been explored to improve the therapeutic index of cytotoxic drugs. One such prodrug of doxorubicin (Dox), CPI-0004Na [N-succinyl-beta-alanyl-L-leucyl-L-alanyl-L-leucyl-Dox (sALAL-Dox)] has been shown to have ...

The present research developed a new, multi-step approach for hierarchically assessing the Big Five personality domains from a large and diverse pool of existing questionnaire items: those of the California Psychological Inventory (CPI). First, the Abridged Big Five Circumplex (AB5C) structural model was used to organize the CPI item pool in Big Five factor space. Using the 10 resulting CPI-AB5...

Upregulation of the H3K4me3 demethylase JARID1B is linked to acquisition of aggressive, stem cell-like features by many cancer types. However, the utility of emerging JARID1 family inhibitors remains uncertain, in part because JARID1B's functions in normal development and malignancy are diverse and highly context-specific. In this study, responses of oral squamous cell carcinomas (OSCCs) to cat...

Airway hyper-responsiveness (AHR) associated with heightened airway resistance and inflammation is a characteristic feature of asthma. It has been demonstrated that contractile responsiveness and Ca(2+) sensitization to acetylcholine (ACh) in repeated antigen challenge-induced airway hyper-responsive bronchial preparation were significantly increased. The CPI-17 (PKC-potentiated inhibitory prot...

Differential evolution (DE) is a simple and powerful evolutionary algorithm, which has been successfully used in various scientific and engineering fields. Generally, the base and difference vectors of the mutation operator in most of DE are randomly selected from the current population. Additionally, the population information is not fully exploited in the design of DE. In order to alleviate t...

This paper introduces the RIDIRE-CPI, an open source tool for the building of web corpora with a specific design through a targeted crawling strategy. The tool has been developed within the RIDIRE Project, which aims at creating a 2 billion word balanced web corpus for Italian. RIDIRE-CPI architecture integrates existing open source tools as well as modules developed specifically within the RID...

Department of Electrical & Electronic Engineering The University of Hong Kong Pokfulam Road, HONG KONG * Email : [email protected] Email : [email protected] ** In this paper, a new Corrupted-Pixel-Identification (CPI) based estimation filter is presented. The method is especially useful for filtering clustered noise. After the corrupted pixels are identified by the CPI algorithm, the noisy ...