L'hypertrophie virginale ou gigantomastie est une mastopathie rare de cause inconnue. Elle survient au moment de la puberté et se manifeste cliniquement par un accroissement rapide et bilatéral du volume des seins. Les dosages hormonaux sont habituellement normaux et la biopsie du sein montre une accentuation du tissu mésenchymateux. Du fait des complications mécaniques et psychologiques liées ...

Introduction The aim of this 18-month retrospective study was to evaluate the differences in outcomes of denosumab with tumor necrosis factor (TNF) inhibitors (TNFis), tocilizumab (TCZ), or abatacept (ABT) treatment in osteoporosis (OP) patients with rheumatoid arthritis (RA). Patients and methods Patients were divided into TNFis-treated (TNF group; 44 cases), TCZ-treated (TCZ group; 8 cases)...

BACKGROUND On January 1, 2000, Texas began enforcement of a law that requires physicians to notify a parent of a minor child seeking an abortion at least 48 hours before the procedure. METHODS We assessed changes in the rates in Texas of abortions and births (events per 1000 age-specific population) before enforcement of the parental notification law (1998 to 1999) and after enforcement (2000...

This study examined the prevalence of child sexual abuse in a multi-stage stratified probability sample of Afro-American and white-American women, 18 to 36 years of age, in Los Angeles County. The sample ranged in demographic characteristics by age, marital status, education and the presence of children. Of the total sample of 248 women, 154 (62%) reported at least one incident of sexual abuse ...

BACKGROUND Polybrominated diphenyl ethers (PBDEs) are flame retardants found in North American household products during the past four decades. These chemicals leach out in dust as products age, exposing individuals daily through inhalation and ingestion. Animal studies suggest that PBDEs disrupt sex hormones and adversely affect development of the reproductive system. OBJECTIVES In the prese...

Several cardiotonic agents (MCI-154, sulmazole, pimobendan and adibendan) were examined for their ability to influence Ca2+-activated tension development and MgATP-activated tension development in the absence of free Ca2+ (rigor tension), using the chemically skinned fiber from guinea pig papillary muscles. MCI-154, sulmazole, pimobendan and adibendan all increased the tension development induc...

BACKGROUND miRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers. However, its clinical significance in colorectal cancer (CRC) is still unclear. The aim of this study was to analyze the association of miR-154 expression with clinicopathologic features and prognosis in CRC patients. METHODS Quantitative RT-PCR was performed to evaluate miR-154 levels ...

Abstract Introduction Facilitating radiological imaging for patients is an essential task all Foundation Year (FY) doctors. Achieving competence in this can expedite patient management. We evaluated the confidence and skills of FYs facilitating before after introduction formal training. Method Surgical working at a teaching hospital were surveyed to evaluate their baseline level booking discuss...