a new series of 1,2-diaryl-4,5,6,7-tetrahydro-1h-benzo[d]imidazoles, possessing trimethoxy phenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including mcf-7 (breast cancer cell), hepg2 (liver hepatocellular cells), a549 (adenocarcinomic h...

objective(s): this paper aims to investigate synergistic inhibition of polysaccharide from sepia esculenta ink (sip), a newly isolated marine polysaccharide in our laboratory, on breast cancer mda-mb-231 cells exposed to cisplatin. materials and methods: cell viability of mda-mb-231 cells was determined by cck 8 assay. median-effect concentration was analyzed using chou-talalay method that was ...

breast conservation surgery combined with radiation therapy is now an accepted option for the treatment of early breast cancer. so we decided to evaluate the results of such treatment in our first group of patients treated by this method. from 1992 to 1996 , one hundred patients with stage i and ii breast cancer treated with breast conservative surgery (lumpectomy or quadrantectomy). were irrad...

Objective(s): The stress-responsive genes of Sestrin family are recognized as new tumor suppressor genes in breast carcinoma, however, the function of Sestrin family in human prostate cancer is not clear. Ionizing radiation (IR) is known to induce Sestrin gene expression in breast cancer cells. However, the response of Sestrin to IR has not been reported in PC3 prostate cancer cells. Materials ...

Introduction: Marine actinomycetes have a great potential to produce unique bioactive compounds due to their special adaptation in the harsh ocean environment. The current study aimed to isolate anti-cancer compounds producing actinomycetes from sediments of Harra forests of the Persian Gulf and investigate their potential as anti-breast cancer metabolites. Methods: In the current study, 40 se...

Introduction: Marine actinomycetes have a great potential to produce unique bioactive compounds due to their special adaptation in the harsh ocean environment. The current study aimed to isolate anti-cancer compounds producing actinomycetes from sediments of Harra forests of the Persian Gulf and investigate their potential as anti-breast cancer metabolites. Methods: In the current study, 40 se...

Naringenin is a natural compound with potential anti-cancer effects against several cancer types.  Also, its precise molecular mechanisms regarding tumor growth suppression has not been completely elucidated. In the current study the apoptosis-inducing and anti-proliferative effects of Naringenin together with cyclophosphamide were studied in breast cancer cells and the participation of JAK2/ST...