SLC22A18 [solute carrier family 22 (organic cation transporter) member 18] is located within the 11p15.5 cluster, and may be a new tumor suppressor gene; evidence of SLC22A18 hypermethylation is documented in several types of human cancers. In order to determine whether SLC22A18 hypermethylation is involved in glioma, we determined the SLC22A18 gene protein expression, mRNA expression and methy...

Introduction:It is well-recognized that collimator-detector response (CDR) is the main image blurring factor in SPECT.  In this research, we compensated the images for CDR in molecular SPECT by using STIR reconstruction framework. Methods: To assess resolution recovery capability of the STIR, a phantom containing five point sources along with a micro Derenzo p...

dependent variables that were selected for study were, particle size (Y ) and % drug entrapment (Y ). The derived 1 2 polynomial equations were verified by check point formulation. The application of factorial design gave a statistically systematic approach for the formulation and optimization of nanoparticles with desired particle size, % drug release and high entrapment efficiency. Drug:polym...

The study was performed to determine the gestational age of preterm infants that requires amikacin therapeutic drug monitoring. A study was conducted in preterm infants on amikacin therapy with gestational age of 28 to 36 weeks. Therapeutic drug monitoring in preterm infants was performed based on their individual pharmacokinetics to avoid ototoxicity and nephrotoxicity. Its prerequisite, becau...

Introduction: The term connect comes from the Latin word `Connecture', meaning ̀ to bind'.1 It originates from the mesenchyme that is the middle layer of three embryonic germ layers. Connective tissue is a tissue that supports and connects other tissues and parts. The main bulk of the tissue consists of intercellular substance or matrix, whereas rests of the tissue are cells, comprises of compar...

Evaluating satellite-based products is vital for precipitation estimation sustainable water resources management. The current study evaluates the accuracy of predicting using four remotely sensed rainfall datasets—Tropical Rainfall Measuring Mission (TRMM-3B42V7), Precipitation Estimation from Remotely Sensed Information Artificial Neural Networks Climate Data Records (PERSIANN-CDR), Cloud Clas...

BACKGROUND Antibody phage display is a proven key technology that allows the generation of human antibodies for diagnostics and therapy. From naive antibody gene libraries - in theory - antibodies against any target can be selected. Here we describe the design, construction and characterization of an optimized antibody phage display library. RESULTS The naive antibody gene libraries HAL9 and ...

OBJECTIVE To determine whether clinical assessment methods that grade the severity of impairments within the spectrum of mild cognitive impairment (MCI) can predict clinical course, particularly among very mildly impaired individuals who do not meet formal MCI criteria as implemented in clinical trials. DESIGN Cohort. SETTING Community volunteers. PARTICIPANTS From a longitudinal study of...

BACKGROUND The Clinical Dementia Rating (CDR) scale is widely used to assess cognitive impairment in Alzheimer's disease. It requires collateral information from a reliable informant who is not available in many instances. We adapted the original CDR scale for use with elderly subjects without an informant (CDR-NI) and evaluated its reliability and validity for assessing mild cognitive impairme...