The early administration of tranexamic acid (TXA) to bleeding trauma patients reduces all-cause mortality without increasing the risk of vascular occlusive events. Indeed, the risk of arterial thrombosis appears to be reduced with TXA. In this commentary we hypothesize that TXA has an antithrombotic effect and explore potential mechanisms. These include inhibition of the inflammatory effects of...

A very careful enquiry within adequate sub-samples of the general population of a market town and its surrounding villages has revealed (a) no special relationship between so-called tension headaches and migraine as defined; (b) a two-year prevalence of migraine more or less similar to that reported elsewhere, i.e. approximately 10% of males and 25% of females being affected; (c) a greater prev...

This study examines the importance of job characteristics on absence and on-the-job performance in a large group of employees with diagnosed depressive and anxiety disorders. In a sample of 1522 employees (1129 persons with and 393 persons without psychopathology) participating in Netherlands Study of Depression and Anxiety (NESDA, n=2981) we examined associations between job characteristics an...

Ten tension headache sufferers (TH) were compared with ten anxious neurotics (AN) and ten normal subjects in terms of electrodermal responses habituation (RH). TH sufferers showed less impaired RH than AN group, the normals showed least impairment. Moreover, it was evident that phasic elevation of electrodermal responses, rather than tonic measure, was a better indicator of individual differenc...

the aim of this study was to compare the level of anxiety and depression in patients admitted to surgery or internal departments. the study was carried out on 359 hospitalized patients over the age of 18 years and designed as a cross sectional survey. participants were recruited from internal medicine and surgery departments of khatam al anbia hospital, tehran, iran. information was collected u...

Depression involves either enhanced processing of negative stimuli or diminished processing of positive stimuli. We used functional magnetic resonance imaging to assess brain activation in depressed vs healthy participants. Fifteen participants diagnosed with major depressive disorder and 15 controls were scanned during a lexical decision task involving neutral, happy, sad, and threat-related w...

Studies of regional hemispheric asymmetries point to relatively less activity in left frontal and right posterior regions in depression. Anxiety was associated with increased right posterior activity, which may be related to arousal and, in anxious-depressed individuals, offset the posterior asymmetry typically seen in depression. These asymmetries have been indexed by resting EEG or inferred t...