We present a compilation of over 1700 focal mechanisms for nearly 1300 earthquakes in metropolitan France and bordering regions Western Europe. It is based on both published unpublished sources (articles, reports, observatory websites) which the mechanism solutions have been verified internal consistency, corrected cases minor errors rejected major inconsistencies between parameters. The databa...

Accurate P-wave first-motion-polarity (FMP) information can contribute to solving earthquake focal mechanisms, especially for small earthquakes, which waveform-based methods are generally inapplicable due the computationally expensive high-frequency waveform simulations and inaccurate velocity models. In this paper, we propose a deep-learning-based method automatic determination of FMPs, named ...

The paradigmatic assumption that REM sleep is the physiological equivalent of dreaming is in need of fundamental revision. A mounting body of evidence suggests that dreaming and REM sleep are dissociable states, and that dreaming is controlled by forebrain mechanisms. Recent neuropsychological, radiological, and pharmacological findings suggest that the cholinergic brain stem mechanisms that co...

The blood-brain barrier (BBB) is a network formed mainly by brain microvascular endothelial cells (BMECs). The integrity of the BBB is critical for brain function. Breakdown of the BBB is commonly seen in AIDS patients with HIV-1-associated dementia despite the lack of productive HIV infection of the brain endothelium. The processes by which HIV causes these pathological conditions are not well...

Prickle is known to be involved in planar cell polarity, including convergent extension and cell migration; however, the detailed mechanism by which Prickle regulates cellular functions is not well understood. Here, we show that Prickle1 regulates front-rear polarization and migration of gastric cancer MKN1 cells. Prickle1 preferentially accumulated at the cell retraction site in close proximit...

Interaction of integrins with the extracellular matrix leads to transmission of signals, cytoskeletal reorganizations, and changes in cell behavior. While many signaling molecules are known to be activated within Rac-induced focal complexes or Rho-induced focal adhesions, the way in which integrin-mediated adhesion leads to activation of Rac and Rho is not known. In the present study, we identi...

Localization of sources in patients with focal seizure has recently attracted many attentions. In the severe cases of focal seizure, there is a possibility of doing neurosurgery operation to remove the defected tissue. The prosperity of this heavy operation completely depends on the accuracy of source localization. To increase this accuracy, this paper presents a new weighted beamforming method...

Introduction: Optimal radiopacity is one of the properties required for a root canal sealer that helps the distinction between the sealer and surrounding anatomic structures and evaluation of the quality of root filling. So, the purpose of this study was to evaluate the radiopacity of six root canal sealers at different focal distances. Materials and Methods: In this in vitro study, six endodo...

BACKGROUND We used intravascular ultrasound (IVUS) to (1) clarify the mechanisms of luminal loss after drug-eluting stent (DES) implantation and (2) classify morphological patterns of in-stent restenosis (ISR). METHODS AND RESULTS On the basis of IVUS-identified luminal narrowing (in-stent minimum lumen area <4 mm(2)), IVUS-defined ISR was classified as focal (luminal narrowing ≤10 mm in leng...