Stroke is the most common type of cerebrovascular disease and is a leading cause of disability and death. Ischemic stroke accounts for approximately 80% of all strokes. The remaining 20% of strokes are hemorrhagic in nature. To date, therapeutic options for acute ischemic stroke are very limited. Recent research suggests that shifting microglial phenotype from the pro-inflammatory M1 state towa...

BACKGROUND Previous studies have demonstrated that glial cells play an important role in the generation and maintenance of neuropathic pain. Activated glial cells produce numerous mediators such as proinflammatory cytokines that facilitate neuronal activity and synaptic plasticity. Similarly, bladder pain syndrome/interstitial cystitis shares many characteristics of neuropathic pain. However, r...

Abstract Introduction Recent studies have found that mid-life sleep disruption is associated with the development of Alzheimer’s disease-related neuropathology, including deposition amyloid beta. Yet, mechanism connecting disruption, particularly over chronic timescales, and downstream pathology remains unclear. Methods In this study, we evaluated impact has on neuroinflammation beta plaques in...

Background: The effects of Pb-induced neurotoxicity have been largely established; however, the need for proper neuroprotective agents to mitigate remains vague. Objectives: This study aimed at investigating pre-treatment with vitexin and C. cajan extract against in Wistar rats. Methods: Twenty-four male rats were randomly assigned into four groups (n=6). control group was administered 0.5 mL d...

Indomethacin (INDO) demonstrates therapeutic efficacy in the treatment of neuroinflammatory diseases. Despite its importance as a drug, INDO causes gastrointestinal problems and adverse reactions central nervous system (CNS). In this study, we prepared nanoparticles layered double hydroxide (LDH) loaded with INDO. The structure nanohybrid (LDH-INDO) was synthesized via coprecipitation method, c...