Pregnancy increases the urinary excretion of chemicals in women and rodents. It is unknown whether the enhanced clearance of drugs during pregnancy involves changes in the expression of transporters that mediate chemical secretion and reabsorption. The purpose of this study was to quantify the mRNA and protein expression of efflux transporters in kidneys from virgin and pregnant mice on gestati...

Focus Mar. 2003 Volume 25.1 3 incorporation into product during PCR. The design is based on the effects of the primary and secondary structure of oligonucleotides on the emission properties of attached fluorescent dyes (6). The design factors are used in a proprietary primer design software, called LUXTM Designer, that is used to design and order fluorogenic LUXTM Primers and unlabeled counterp...

Pregnancy increases the urinary excretion of chemicals in women and rodents. It is unknown whether the enhanced clearance of drugs during pregnancy involves changes in the expression of transporters that mediate chemical secretion and reabsorption. The purpose of this study was to quantify the mRNA and protein expression of efflux transporters in kidneys from virgin and pregnant mice on gestati...

Abstract Study question Dose the follicular fluid-derived exosomes rejuvenate ovarian aging? Summary answer Follicular efficiently rescued function in aged mice, which was achieved via transfer of miR-320-3p to granulosa cells and subsequent Foxq1 inhibition. What is known already The ovary enters malfunctional aging phase earlier faster than other organs systems. Ovarian mainly characterized b...

background:   objective: to understand the changes of mirnas in endometriosis.   materials and methods: with real-time rt-pcr, we investigated the mir-143 and mir-145 expression in eutopic (eu, n=2) and ectopic endometrium (ec, n=11) (from women with endometriosis) (as well as eu+ec, n=11), along with the normal endometrium (en, n=22) (from women without endometriosis, but with leiomyoma). resu...

Background: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. Studies revealed that microRNAs (miRNAs) can function as oncogenes or tumor suppressors in CLL and that the expression of miRNAs, such as miR-193b-3p and miR-376a-3p change in several diseases. We aimed to elucidate the changes in miR-193b-3p and miR-376a-3p expression in CLL and determine their potential as...