نتایج جستجو برای: pharmacological models
تعداد نتایج: 976571 فیلتر نتایج به سال:
advances in understanding the neurobiology of addiction to stimulants, has made it possible for researchers to identify medicines effective in initiation of treatment and prevention of stimulants relapse, based on pharmacological effects of various medicine. some of these medicine and vaccines have brought promising results in clinical trials on cocaine dependent patients. studies regarding met...
Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron. Ho...
To increase our understanding of drug addiction--notably its pharmacological and neurobiological determinants--researchers have begun to formulate computational models of drug self-administration. Currently, one can roughly distinguish between three classes of models which all have in common to attribute to brain dopamine signaling a key role in addiction. The first class of models contains qua...
OBJECTIVE To evaluate the association between the number of pharmacological inappropriateness and possible factors related with it. METHODS All polyphatological patients of the IMPACTO project in a tertiary hospital were included (July 2010-March 2012). The pharmacist performed the interventions based on a combined strategy that included the modified MAI and the STOPP-START criteria. A greate...
The most frequently used animal models of early weaning (EW) in rodents, maternal deprivation and pharmacological inhibition of lactation, present confounding factors, such as high stress or drug side effects, that can mask or interact with the effects of milk deprivation per se. Given these limitations, the development of new models of EW may provide useful information regarding the impact of ...
RATIONALE There are several methods to measure cardiomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and advanced informatics or can only be used in single experimental models. Consequently, data and techniques have been difficult to reproduce across models and laboratories, analysis is time consuming, and only specialist researchers can quantify data...
Deep brain stimulation at high frequencies (HFS) is currently studied in the treatment of therapy-refractory obsessive-compulsive disorder (OCD). The diversity of targeted brain areas and the discrepancy in demonstrating beneficial effects, highlight the need for better mapping of brain regions in which HFS may yield anti-compulsive effects. This goal may be achieved by investigating the effect...
Urtica dioica is a perennial plant used as herbal medicine due to its many pharmacological and clinical effects. Because of its antioxidant activity, it is widely used in traditional diabetes treatment but is also known as antimicrobial, anti inflammatory or anti prostate cancer agent. Extensive studies have been conducted on different parts of this plant and their biological effects. Here...
The discovery of chemotherapeutic agents for the treatment of cancer commonly uses cell proliferation assays in which cells grow as two-dimensional (2D) monolayers. Compounds identified using 2D monolayer assays often fail to advance during clinical development, most likely because these assays do not reproduce the cellular complexity of tumors and their microenvironment in vivo. The use of thr...
In conventional pharmacological studies, intersubject differences within an animal strain are normally neglected, leading to variations in pharmacological outcomes in response to the same stimulus. Using two classical experimental models, the Streptozotocin (STZ)-induced diabetic model of Wistar rats and the high-energy, diet-induced obesity model of Sprague-Dawley rats, we demonstrate that the...
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