BACKGROUND The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and...

BACKGROUND Most models of successful ageing do not allow for the possibility of living "successfully," despite some degree of cognitive or physical impairment. We reviewed the successful ageing and related quality of life literature to identify their potential predictors. We then tested our hypotheses that wellbeing in adversity would be predicted by mental health (anxiety and depression) and s...

background: increased life expectancy and the growing phenomenon of aging can lead to increased burden of chronic diseases (cds) which adversely affects the overall health of elderly, their sexuality in particular. sexual life of aged population is overlooked in many of the societies. in the present narrative review, we aim to assess the impact of cds on sexual function of elderly people. mater...

introduction: motor skills play an important role during life span, and older adults need to learn or relearn these skills. the purpose of this study was to investigate how aging affects induction of improved movement performance by motor training. methods: serial reaction time test (srtt) was used to assess movement performance during 8 blocks of motor training. participants were tested in two...

Traditional methods for phenotyping skeletal muscle (e.g., immunohistochemistry) are labor-intensive and ill-suited to multixplex analysis, i.e., assays must be performed in a series. Addressing these concerns represents a largely unmet research need but more comprehensive parallel analysis of myofibrillar proteins could advance knowledge regarding age- and activity-dependent changes in human m...

BACKGROUND The demographic development with an ageing population is predicted to be the next global public health challenge. Advances in medicine and the socioeconomic development have reduced mortality and morbidity due to infectious conditions and non-communicable diseases. The increase in longevity will not be restricted to healthy people. OBJECTIVE To understand how people with muscular d...

The ageing of the bitumen during storage, mixing, transport and laying on the road, as well as in service life, are the most important problems presented by the use of bitumen in pavements. This paper investigates the possibility of using waste cooking oil (WCO), which is a waste material that pollutes landfills and rivers, as an alternative natural rejuvenating agent for aged bitumen to a cond...

BACKGROUND Considering that physical activity is associated with healthy ageing and helps to delay, prevent, or manage a plethora of non-communicable diseases in older adults, there is a need to investigate the factors that influence physical activity participation in this population. Thus, we investigated physical activity correlates among community-dwelling older adults (aged ≥50 years) in si...