human immunodeficiency virus infection / acquired immunodeficiency syndrome (hiv/aids) is a disease pertained to the human immune system. given its crucial role in viral replication, hiv-1 protease (hiv-1 pr) is a prime therapeutic target in aids therapy. in this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in hiv-1 pr in...

In recent times, multilevel inverters (MLIs) are gaining popularity for grid integration of distributed power generation sources. this paper, a proportional-resonant (PR) controller based on current control logic is proposed single-phase eleven-level inverter topology, enabling the sources into grid. The presented topology utilizes eight two-quadrant switches and three dc to produce an output v...

conclusions the use of sof + pr regimen or ldv/sof can significantly reduce the incidence of complications associated with the disease. for example, short and long-term outcomes are better than the current drug regimens for hcv genotype 1 patients in all stages of the disease. objectives this study is aimed to assess the cost-effectiveness of the three drug regimens of pegylated interferon and ...

This paper presents a neural network model with a variable structure, which is trained by genetic algorithm (CA). The proposed neural network consists of a Neural Network with a Node-to-Node Relationship (PR) and a Network Switch Controller (NSC). In the N'R, a modified neuron model with two activation functions in the hidden layer, and switches in its links are introduced. The NSC controls the...

A risk of covert insertion of circuitry into reconfigurable computing (RC) systems exists. This paper reviews risks of hardware attack on field programmable gate array (FPGA)-based RC systems and proposes a method for secure system credentials generation (unique, random and partially anonymous) and trusted self-reconfiguration, using a secure reconfiguration controller (SeReCon) and partial rec...

This paper aims to design an optimal distributed multi-agent controller for load frequency control and optimal power flow purposes. The controller parameters are optimized using Grey Wolf Optimization (GWO) algorithm. The designed optimal distributed controller is employed for load frequency control in the IEEE 30-bus test system with six generators. The controller of each generator is consider...

this article presents a fuzzy robust mixed - sensitivity gain - scheduled h controller based on the loop -shaping methodology for a class of mimo uncertain nonlinear time - varying systems. in order to design this controller, the nonlinear parameter - dependent plant is first modeled as a set of linear subsystems by takagi and sugeno’s (t - s) fuzzy approach. both loop - shaping methodology and...

The progesterone receptor (PR) has three isoforms, PR-A, PR-B, and PR-C, which have different physiological effects. PR-A may inhibit PR-B-mediated transcription. Parturition requires withdrawal of progesterone (P4). This could occur through decreased P4 concentrations and/or a change in PR isoforms to diminish the effect of P4. We measured mRNA for PR isoforms in rat uterine tissues through la...