charcot-marie-tooth disease (cmt) is the most common inherited neurological disorder, affecting both motor and sensory peripheral nerves. neurophysiological patterns divide cmt into three main groups: demyelinating cmt1 (upper limb motor nerve conduction velocity (mncv) <38 m/s), axonal cmt2 (mncv >38 m/s) and intermediate cmt (mncv 25-45 m/s). cmt has been also categorized based on the mode of...

background: blunt abdominal trauma is one of the causes of mortality in emergency department. free fluid in the abdomen due to intra-abdominal blunt trauma can be determined by the surface probe of ultrasound. since the importance of this free fluid in hemodynamic stable patients with blunt trauma is associated with the unknown outcome for surgeons, this study was performed to evaluate the role...

The molecular properties known to play an essential role in drug-receptor interaction of substructures models of bioactive molecules have been studied using chemical quantum calculations. 1,4-diformyl-piperazine and 1,4-dithionyl-piperazine have been used as models to probe conformational behaviors and some electronic properties of substructure of some tri-substituted piperazine showing dual an...

A subset of co-crystal systems the antipyretic and analgesic drug, propyphenazone, are used to probe nature drug···co-former interactions. The experimental electron density distribution, based on very high-resolution single crystal diffraction, has been modelled an analysis undertaken using Bader's Atoms in Molecules approach. Atomic charges, intermolecular interactions their energies have subs...

Understanding the potential for cytochrome P450 (P450)-mediated drug-drug interactions is a critical part of the drug discovery process. Factors such as nonspecific binding, atypical kinetics, poor effector solubility, and varying ratios of accessory proteins may alter the kinetic behavior of an enzyme and subsequently confound the extrapolation of in vitro data to the human situation. The arch...

The effectiveness of the potent antifungal drug fluconazole is being compromised by the rise of drug-resistant fungal pathogens. While inhibition of Hsp90 or calcineurin can reverse drug resistance in Candida, such inhibitors also impair the homologous human host protein and fungal-selective chemosensitizers remain rare. The MLPCN library was screened to identify compounds that selectively reve...

Mycobacterium tuberculosis is a pathogenic organism, which causes high morbidity and mortality in human being. The disease tuberculosis is commonly seen in immunocompromised patients. M. tuberculosis takes time to grow on culture medium (Lowenstein-Jensen medium) for drug susceptibility testing to avoid delay, now a day molecular techniques are introduced in many developing countries including ...