BACKGROUND AND OBJECTIVES Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor under clinical investigation in solid tumours. This study evaluated the influence of P-glycoprotein (P-gp) inhibition (single-dose rifampicin) and simultaneous cytochrome P450 3A4 (CYP3A4)/P-gp induction (multiple-dose rifampicin) on lenvatinib pharmacokinetics. METHODS This Phase I, single-centre, single...

Two studies were performed to evaluate early pregnancy diagnosis by transrectal ultrasonography (TRUS), using a 7.5-MHz ransducer in ewes. In the first study, the objectives were to determine the earliest date that a reliable pregnancy diagnosis could be ade (percentage of ewes detected pregnant between days 15 and 20 after mating). In the second study, the objective was to confirm he findings ...

Di(n-butyl) phthalate (DBP), a widely used plasticizer suspected of having estrogenic properties, was investigated for its effects on the prenatal and early neonatal development of the reproductive tract. Pregnant CD rats (n = 10) were given DBP at 0, 250, 500, or 750 mg/kg/day (p.o.) throughout pregnancy and lactation until their offspring were at postnatal day 20. Maternal body weights throug...

The effects of high ambient temperature and level of dietary heat increment on sow milk production and piglet performance over a 28-d lactation were determined in 59 multiparous crossbred Large White x Landrace pigs kept at a thermoneutral (20 degrees C) or in a hot (29 degrees C) constant ambient temperature. Experimental diets fed during lactation were a control diet (NP; 17.6% CP) and two lo...

INTRODUCTION A post hoc analysis of three randomized controlled trials of abatacept in rheumatoid arthritis (RA) was conducted to explore the effect of abatacept on fatigue in RA and its correlation with other outcomes. METHODS In this analysis of AGREE (early RA) and AIM and ATTAIN (established RA), changes in baseline fatigue (0-100 mm scale), pain, sleep (AIM and ATTAIN only) and Disease A...

demographic parameters of the pink stem borer, sesamia creticalederer (lepidoptera: noctuidae) were estimatedon its two main host plants, maize and sugarcane. the present studywas conducted under laboratory conditions at 27±1˚c, 50±10% relative humidity (rh %), and a photoperiod of 0:24 (l:d) hour for the larval stage and 16:8 (l:d) hour for the other life stages. the raw data were analyzed bas...

BACKGROUND Many patients with advanced non-small-cell lung cancer (NSCLC) do not tolerate cisplatin-based regimens because of its nonhemathological toxicity. PATIENTS AND METHODS We evaluated the response rate safety of new platinum analogue regimens, randomizing 147 patients with nonoperable IIIB/IV NSCLC to (i) carboplatin (area under the curve = 5 mg min/ml) on day 1 plus gemcitabine (GEM)...