BACKGROUND Bipolar disorder (BPD) is the Axis I disorder with the highest risk for coexisting substance use disorder. One explanation for this phenomenon is the 'self-medication hypothesis', which states that some patients experience improvement in psychiatric symptoms as a result of substance use. We thus investigated reasons for substance use and perceived substance-induced improvement in BPD...

Anxiety sensitivity (AS) has been linked to both pathological anxiety and substance use problems. We evaluated relations between AS and substance use situations among individuals with substance use disorders (SUDs) and concurrent DSM-IV anxiety disorders. We predicted that AS would be most strongly associated with substance use in situations involving negative emotions and interpersonal conflic...

The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg1, D-Trp7.9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7.9, Leu11]-substance P, but not by [D-Pro2, D-Trp7,9]-substance P. The profiles of protein...

conclusions the results of this study in terms of personality disorders and types of used drugs were in accordance with the previous studies results. it is necessary to design appropriate treatment plans for medical treatment of those with personality disorders. results there was a significant correlation between stimulant use and histrionic personality disorder (p < 0.001) and antisocial and n...

background: several studies have shown that attentional bias plays a role in the beginning, persistence and relapse of substance abuse disorder. therefore, identifying the factors related to attentional bias in substance abusers is important. in so doing, the present study was aimed at examining the relationship between attentional bias, anxiety sensitivity and metacognitive beliefs in substanc...

comorbidity between borderline personality disorder and substance abuse disorder is very high. the present study examined the effectiveness of dialectical behavior therapy on negative emotion regulation strategies in women with borderline personality disorder and substance abuse. based on the willingness to participate in the research, structured clinical interview and the criteria for inclusio...

BACKGROUND A number of cognitive deficits are associated with dyslexia. However, only a limited amount of research has been performed exploring a putative link between dyslexia and substance use. As substance use is thought to involve a cognitive component, it is possible that the pattern of substance use would be different for dyslexic participants, when compared to nondyslexic controls. Durin...

If a person expects that (a) drinking alcohol or using another addictive substance will enhance positive affect or reduce negative affect, and (b) there is a strong likelihood that these desirable consequences will occur if the substance is used, that person is likely to form a goal of using the substance. The theoretical framework presented here predicts that when that happens, the person will...