Three varieties of Hibiscus sabdariffa were analyzed for their phytochemical content and inhibitory potential on carbohydrate-digesting enzymes as a basis for selecting a variety for wine production. The dark red variety was chosen as it was highest in phenolic content and an aqueous extract partially inhibited α-glucosidase (maltase), with delphinidin 3-O-sambubioside, cyanidin 3-O-sambubiosid...

Inhibition of maltase, sucrase, isomaltase and glucoamylase activity by acarbose, epigallocatechin gallate, epicatechin gallate four polyphenol-rich tea extract from white, green, oolong, black tea, were investigated using rat intestinal enzymes human Caco-2 cells. Regarding enzyme mixture, all extracts very effective in inhibiting maltase activity, but only white inhibited sucrase the inhibiti...

α-Glucosidase inhibition is considered as an effective strategy for the treatment of diabetes mellitus. Currently, three α-glucosidase inhibitors are being used drugs; Acarbose, Voglibose and Miglitol. The side effects these drugs forcing researchers to search new molecules. In this research work, novel 1,2,3-benzotriazin-4(3H)-one sulfonamides were synthesized investigated their activity. 2,4,...

Objective: This research was conducted to determine inhibition activity of curcumin nanoparticles against α-amylase and α-glucosidase enzymes.
 Methods: Curcumin nanoparticle made by ionic gelation method using chitosan as cation, sodium tripolyphosphate polyanion, tween 80 surfactant. were tested for inhibitory enzymes UV-Vis spectrophotometry at λ= 595 nm 305 nm, respectively.
 Resu...

α-Glucosidase is in the glycoside hydrolase family 13 (13AG) and 31 (31AG). Only 31AGs can hydrate the D-glucal double bond to form α-2-deoxyglucose. Because 1,5-anhydrofructose (AF), having a 2-OH group, mimics the oxocarbenium ion transition state, AF may be a substrate for α-glucosidases. α-Glucosidase-catalyzed hydration produced α-glucose from AF, which plateaued with time. Combined reacti...

The amino acid and fatty acid composition of polypeptide k and oil isolated from the seeds of Momordica charantia was analysed. The analysis revealed polypeptide k contained 9 out of 11 essential amino acids, among a total of 18 types of amino acids. Glutamic acid, aspartic acid, arginine and glycine were the most abundant (17.08%, 9.71%, 9.50% and 8.90% of total amino acids, respectively). Fat...

BACKGROUND In Chinese traditional medicine, Agrimonia pilosa Ledeb (APL) exhibits great effect on treatment of type 2 diabetes mellitus (T2DM), however its mechanism is still unknown. Considering that T2DM are correlated with postprandial hyperglycemia and oxidative stress, we investigated the α-glucosidase inhibitory activity and the antioxidant activity of flavonoid compound (FC) and triterpe...