AIMS Patients with diabetes have increased risk of in-stent restenosis after coronary stent implantation owing to neointimal hyperplasia (NIH). The aim of the study was to evaluate the extent and distribution of NIH with intravascular ultrasound (IVUS) after coronary artery stenting with sirolimus-eluting (Cypher) or paclitaxel-eluting (Taxus) stents in diabetic patients. METHODS AND RESULTS ...

In inflammatory states, nitric oxide (.NO) may be synthesized from precursor L-arginine via inducible .NO synthase (iNOS) in large amounts for prolonged periods of time. When .NO acts as an effector molecule under these conditions, it may be toxic to cells by inhibition of iron-containing enzymes or initiation of DNA single-strand breaks. In contrast to molecular targets of .NO, considerably le...

In a previously reported investigation of 616 women with breast cancer included in a case-control study, we found an association between tumour stage at presentation and breast self examination (BSE) (Mant et al., 1987). Women who had both practised and been taught BSE had more favourably staged tumours than other women. A number of other studies, summarised in the meta-analysis by Hill et al. ...

BACKGROUND Intense interest surrounds the recent expansion of US National Institutes of Health (NIH) budgets as part of economic stimulus legislation. However, the relationship between NIH funding and cardiovascular disease research is poorly understood, making the likely impact of this policy change unclear. METHODS The National Library of Medicine's PubMed database was searched for articles...

Recently, we reported that defective autophagy may contribute to the inhibition of the growth in response to PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), a selective SFK inhibitor, in multidrug-resistant v-Ha-ras-transformed NIH 3T3 cells (Ras-NIH 3T3/Mdr). In this study, we demonstrated that PP2 induces LC3 conversion via a mechanism that is uncoupled from autophagy a...

320. VRE Colonization and Infection at the NIH Clinical Center (NIHCC) Heather Y. Hughes, MD; Robin T. Odom, MS; Angela V. Michelin, MPH; Evan S. Snitkin, PhD; David K. Henderson, MD, FIDSA; Tara N. Palmore, MD; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD; Hospital Epidemiology Service, National Institutes of Health Clinical Center, NIH, Bethesda, MD; National Human...