IL-12p70, a 70- to 75-kDa heterodimer consisting of disulfide-bonded 35-kDa (p35) and 40-kDa (p40) subunits, enhances Th1 development primarily by its ability to induce IFN-gamma production by NK and Th1 cells. Although homodimers of the p40 subunit of IL-12 are potent IL-12 receptor antagonists in some systems, we have reported that p40 homodimer may accentuate alloreactive CD8+ Th1 function. ...

Interleukin-12 (IL-12), a cytokine with in vitro and in vivo immunomodulatory effects, is produced mostly by activated monocytes and macrophages. To study the effect of human immunodeficiency virus (HIV) infection on IL-12 production, we investigated the expression of IL-12 at mRNA and protein levels by human monocytes preincubated with HIV-gp120. In these conditions, we show that monocytes hav...

OBJECTIVE The objective of this study was to evaluate the presence of vitamin B12 deficiency and the factors associated with serum vitamin B12 levels in a sample of metformin-treated Brazilian diabetic patients. METHOD Cross-sectional study. RESULTS 144 patients were included. Serum vitamin B12 levels were low (< 125 pmol/L) in 10 patients (6.9%) and possibly low (125 - 250 pmol/L) in 53 pa...

Electrodiagnostic Studies in Neurologically Asymptomatic Patients with Vitamin B12 Deficiency Füsun Mayda DOMAÇ, Geysu KARLIKAYA, Yılmaz ÇETİNKAYA, Mehmet GENCER, Tülin TANRIDAĞ, Önder US Erenköy Mental and Neurological Disease. Training and Research Hospital, İstanbul Acıbadem University, Department of Neurology, İstanbul Haydarpaşa Numune Training and Research Hospital, Department of Neurolog...

Serum Acylcarnitines and Vitamin B12 Deficiency, Mark M. Kushnir, Bori Shushan, William L. Roberts, and Marzia Pasquali ( ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108; 2 MDS SCIEX, Concord, ON, L4K 4V8 Canada; 3 Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132; * author for correspondence: fax 801-584-5207, email kushnm...