1. Although in blood cells decreased magnesium concentrations and increased sodium concentrations in essential hypertension have often been described, only sparse data exist on cellular magnesium or sodium content and exchange in vascular smooth muscle cells.2. Therefore in aortic smooth muscle cells from 10 spontaneously hypertensive rats (SHR) of the Münster strain and 10 normotensive Wistar-...

OBJECTIVE To determine the median interpregnancy maternal weight change between first and second pregnancies, and second and third pregnancies and to assess the impact of this weight change on pregnancy outcome in a cohort of women with a macrosomic first delivery. STUDY DESIGN Prospective longitudinal study conducted over three pregnancies from 2007 to 2015. SETTING Tertiary referral mater...

Pharmacokinetic parameters of 2-(allylthio)pyrazine (2-AP) were evaluated after i.v. administration of the drug (10, 20, 50, and 100 mg/kg body weight) and oral administration of the drug (10, 50, and 100 mg/kg body weight) to rats. The hepatic, gastric, and intestinal first-pass effects of 2-AP were also measured after i.v., intraportal, intraduodenal, and oral administration of the drug (10 a...

Figure 3. Toxicokinetic profiles for PCB-153, PCB-180, and HCB blood concentration for (A) normal body weight history and 10 ng/kg/day exposure to each of these chemicals for a woman who was not breast-fed in childhood (blue line) or breast-fed for 6 months (black line); (B) normal weight (gray line), weight loss (black line), or overweight (blue line) profiles and 10 ng/kg/day exposure to each...

Correlated responses in reproductive and carcass traits from a line of Duroc pigs selected for increased 200-d weight along with a randomly selected control line were studied in 189 litters (116 select, 73 control) and 191 pigs (106 select, 85 control), respectively. Reproductive and maternal traits studied included litter sizes born, born alive, and alive at 21 d and litter weight at birth and...

the experiment was designed to study the changes in production performance and egg quality of old laying hens after injection of different doses of growth hormone (gh) and testosterone (ts). a total of 160 old laying hens (hyline w-36) at 73 wks of age were randomly assigned to four treatments with four replicates and 10 birds in each replicate in a completely randomized design. treatment group...

BACKGROUND The purpose of this study was to evaluate the effects of milnacipran on body weight in patients with fibromyalgia. METHODS ANALYSES WERE CONDUCTED IN THE FOLLOWING GROUPS: patients from three double-blind, placebo-controlled milnacipran trials (3 months, n = 2096; 6 months, n = 1008); 354 patients receiving milnacipran in placebo-controlled trials and double-blind extension studies...

BACKGROUND How weight change affects the metabolic syndrome (MS) and its parameters is unknown, particularly, in a leaner European population such as the French prospective D.E.S.I.R. cohort. METHODS In 3770 D.E.S.I.R. participants (sex ratio=1) averaging 47.5 years (range 30-64), with measured weight and MS parameters at baseline (D0) and at 6 year follow-up (D6), we assessed this relationsh...