This article summarizes the investigation of in-line particle characterization during high shear wet granulation (HSWG) using focused beam reflectance measurement (FBRM) for enhanced process understanding, which is part of an effort to develop this drug product within the framework of quality by design (QbD) and process analytical technology (PAT). Traditionally, the effectiveness of in-line mo...

PM2.5 samples were collected at Tung Chung (TC), Hong Kong, during four nonconsecutive months in 2011/2012 to determine the concentrations, seasonal variations, and potential sources of polycyclic aromatic hydrocarbons (PAHs) n-alkanes (n-C15-n-C35). Samples analyzed using thermal desorption gas chromatography/mass spectrometry (TD-GC/MS) method. The concentrations particulate PAHs ranged from ...

Divertor monitoring pulses (DiMPle) have been run in JET from the C35 campaign onwards. They provide an opportunity to study impurity contamination of plasma when it is limited by different surfaces within machine, as well longer term behaviour impurities. In these discharges first on outer wall, then inner wall and, subsequently, X-point configuration strike point positioned horizontal tile 5 ...

Climbing the Drug Staircase: A Bayesian Analysis of the Initiation of Hard Drug Use Empirical studies have found that cannabis commonly precedes consumption of drugs like amphetamine, ecstasy, cocaine and heroin. As a result a causal linkage between cannabis and subsequent hard drug use has been hypothesized. Despite mixed empirical evidence and a limited understanding of possible transmission ...

It has been postulated that the perfused rat hindlimb is unsuitable for measurements of muscle glucose transport [P. Hansen, E. Gulve, J. Gao, J. Schluter, M. Mueckler, and J. Holloszy. Am. J. Physiol. 268 ( Cell Physiol. 37): C30-C35, 1995]. The aim of the present study was therefore to critically evaluate the suitability of this preparation for glucose transport measurements using the extrace...

In-School Work Experience, Parental Allowances, and Wages In many industrialised countries, teenagers have a significant spending power, and they are important customers for specialised industries. The income of teenagers still in full time education comes from two major sources: parental pocket money, and earnings from part time jobs. Little is known about the way these sources interact, and h...

Welfare, Labor Supply and Heterogeneous Preferences: Evidence for Europe and the US Following the report of the Stiglitz Commission, measuring and comparing well-being across countries has gained renewed interest. Yet, analyses that go beyond income and incorporate non-market dimensions of welfare most often rely on the assumption of identical preferences to avoid the difficulties related to in...

Although the name for cancer as a disease was coined by ancient Greeks and Persians, and in spite of billions of euros, dollars, and other currencies invested in cancer research, the disease remains a major killer, particularly in Western countries (1). Over half of anticancer drugs, including acetogenins, alkaloids, and terpenes, are derived from natural products, especially from the plant kin...