this study was designed to investigate the therapeutic effects of saffron (crocus sativus l) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (cci) in rats. adult male wistar rats (200 to 250 g) were randomly assigned into 5 groups: sham + saline, cci + saline, cci+ saffron (30 mg/kg), cci +crocin (15 mg/kg) and cci + crocin (30 mg/...

One of the world’s main causes cancer-related fatalities worldwide is colorectal cancer. The adherent epithelial cells known as HCT116 (human carcinoma) are frequently employed to examine inflammatory responses in colonic cells. They derived from human cancer cell line. Crocin, a potent antioxidant, anticarcinogenic was tested this study see how it affected HCT-116 MTT analysis used assess viab...

OBJECTIVE To evaluate the effects of a commercial bleaching agent containing 36% hydrogen peroxide on the clinical plaque index and Streptococcus mutans and Lactobacilli counts in dental plaque and saliva in vivo. METHODS Twenty volunteers were recruited in the present study. Evaluation of plaque index and bacteria counts in plaque and saliva was performed before bleaching the teeth, and 3 da...

Electrochemistry and confocal fluorescence microscopy were successfully combined to selectively bleach and monitor the fluorescence of NBD (7-nitrobenz-2-oxa-1,3-diazole)-labeled phospholipids of giant liposomes. Three types of giant unilamellar vesicles have been investigated, the fluorescent phospholipids being localized either mainly on their outer-, inner-, or both inner/outer leaflets. We ...

Introduction: Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the anti-apoptotic effects of interval and continued training and crocin on diabetic rats. Methods: In this study, 49 adult rats aged eight weeks with diabetes inducaed by a high-fat di...

Antidepressant activity of crocin, saffron main component, has been established before. Based on previous study, it is suggested that elevation in the levels of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide could be considered as one probable molecular mechanisms involved in antidepressant activity of long term crocin administration in the r...

BACKGROUND Laser-assisted bleaching uses laser beam to accelerate release of free radicals within the bleaching gel to decrease time of whitening procedure. The aim of this study was to compare the efficacy of power bleaching using Opalescence Xtra Boost® and laser bleaching technique using LaserSmile gel and diode laser as an activator in their tooth whitening capacity. MATERIAL AND METHODS ...

The essential oil from the aerial parts ofJurinea leptoloba DC., collected from Shiraz (South of Iran), was investigated for total phenolic content (TPC), antioxidant and cytotoxic effects. TPC of J. leptoloba oil was determined to be 16.53 ± 5.69 μg gallic acid equivalent/mg sample (μg GAE/mg oil) using the Folin-Ciocalteau assay. The ferric reducing power of the oil was determined 0.117 ± 0.0...

Introduction: Obesity is known as a multifactorial physical disorder. On the other hand, regular sport exercises and crocin consumption have beneficial effects on obesity. In this regard, the present study aimed to investigate the effect of eight weeks of swimming training with crocin consumption on neurotrophic factors in the heart tissue of obese rats. Methods</strong...

OBJECTIVES This study evaluated the effectiveness of different home bleaching agents on color alteration and their influence on surface and subsurface microhardness of discolored bovine enamel. MATERIAL AND METHODS Forty-five fragments of bovine incisors were randomly allocated into 3 groups (n=15) according to the bleaching agent: 10% carbamide peroxide gel (CP10), 16% carbamide peroxide gel...