Ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. Twenty–four male Wistar rats (250-300 g body wt) were used in this study. The animals were divided into four groups of 6 rat...

Porphyromonas gingivalis has virulence factors such as gingipain and lipopolysaccharide, causing bacteremia to reach the brain activate neuroinflammatory release cytokines. This study analyzed effect of co-culture neuron cells with P. gingivalis coated anti-P. antibodies against cytokines ...

In the treatment of joint diseases, including osteoarthritis (OA), use standardized extracts undenatured type II collagen (UDC-II) is promising. It known that UDC-II involved in regulation innate and adaptive immunity (reduction autoimmune reactions stimulate cartilage degradation) reduction chronic inflammation activity (modulation cytokines prostaglandins). The effect on discoidin receptors c...

Abstract The antiviral innate immune responses are crucial steps during host defense and must be strictly regulated, but the molecular mechanisms of control remain unclear. In this study, we report increased expression human ATPase Na+/K+ transporting subunit β 1(ATP1B1) after DNA RNA virus infections. We found that ATP1B1 can inhibit viral replication increase levels IFNs, IFN-stimulated genes...