Spike-and-wave discharge is an electroencephalographic brainwave found in many rodent species and studied rigorously in inbred laboratory rats (WAG/Rij and GAERS strains) for its similarities to absence epilepsy. The absence epilepsy research field, however, is divided on just how similar SWD in rats is to absence epilepsy in humans. Albino Sprague Dawley rats are an outbred strain used in many...

The experimental carcinogenesis results in six compounds related to vinyl chloride are reported. Vinylidene chloride, given by inhalation, was carcinogenic in male CD-1 mice, male CD rats, Sprague-Dawley rats and male Swiss mice. Trichloroethylene, given by gavage and inhalation, was carcinogenic in the B6C3F1 mice. When given by gavage, perchloroethylene was carcinogenic in the B6C3F1 mice, an...

possibly involved in the regulation of sleep. The present study was designed to investigate the role of brain monoamines in the sleep disorder of MMC-dosed rats and attempts to elucidate the MMC-induced sleep disorder from the standpoint of changes in the concentrations of brain monoamines. MMC was administered orally to 12 Sprague-Dawley male rats 8 weeks age at a dose of 15 mg MMC/kg body wei...

Circulating leptin is elevated in some forms of obesity-related hypertension, associated with impaired baroreflex function. Leptin receptors are present on vagal afferent fibers and neurons within the solitary tract nucleus, providing an anatomic distribution consistent with baroreflex modulation. Although solitary tract nucleus microinjection of 144 fmol/60 nL of leptin had no significant effe...

Ovarian activity has a complex physiology and is related to oocyte quality in women. This study investigates the effects of ovarian with chronic stress (CS) on behavioural parameters, estrous cycles, follicular development rats. Here, we examined microenvironment against exposure elucidate stress-related molecular mechanisms. Twenty female Sprague-Dawley rats were divided into control CS groups...

Many studies have confirmed the traditional use of Ximenia americana (Olacaceae). Its different parts, leaf, fruit, roots, stem bark and root showed pharmacological potentials. X. is a plant which possessed antibacterial, antidiabetic, antiviral anticancer properties. The present study was undertaken to evaluate oral acute subchronic toxicity hydroethanolic extract on Sprague Dawley rats. In te...

Introduction: Cadmium is known to be one of the most noxious environmental and industrial pollutant. Cigarette smoke food products are major sources cadmium exposure in non-occupationally exposed people. Tephrosia lupinifolia DC. (Fabaceae) commonly as Fish poison. It has usage treatment diarrhea, stomachache, urinary disorders, asthma rheumatism. Objectives: This investigation was aimed examin...

objective: ocular morbidity is widely observed when radiotherapy includes the orbit. oxidative stress generated by irradiation is responsible for this complication. in different studies, it has been shown that melatonin has antioxidative properties and a radioprotective role. the aim of this study was to evaluate the antioxidant role of melatonin against radiation-induced oxidative injury in ra...

Abstract The hydrolysate of Oncorhynchus keta (chum salmon) milt was found to exhibit strong inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), and the hypoglycaemic effect these salmon peptides (SMPs) confirmed using oral starch tolerance tests in Sprague–Dawley rats. Specifically, administration SMPs at a dose 300 mg/kg body weight for 1 week resulted significant decrease blood glu...