The development of biomaterial surfaces possessing the topographical cues that can promote mesenchymal stem cell recruitment and, in particular, those capable of subsequently directing osteogenic differentiation is of increasing importance for the advancement of tissue engineering. While it is accepted that it is the interaction with specific nanoscale topography that induces mesenchymal stem c...

background: wharton’s jelly is an unlimited source of stem cells that can be used in cell therapy and tissue engineering without any ethical concern. it has been revealed the cell-free extract could be effective to induce cell differentiation. the objective of this study was to induce wharton’s jelly-derived mesenchymal stem cells (mscs) into hepatocyte-like cells by premeabilization of the cel...

stem cell research has obtained much prominence in recent years for its therapeutic potential in dealing with serious diseases, many of which are essentially incurable by routine therapies. mesenchymal stem cells with pluripotency and immunomodulatory properties are suitable candidates for tissue engineering and regenerative medicine. today, nanofibrous scaffolds are widely used in tissue engin...

OBJECTIVE To characterize equine muscle tissue- and periosteal tissue-derived cells as mesenchymal stem cells (MSCs) and assess their proliferation capacity and osteogenic potential in comparison with bone marrow- and adipose tissue-derived MSCs. SAMPLE Tissues from 10 equine cadavers. PROCEDURES Cells were isolated from left semitendinosus muscle tissue, periosteal tissue from the distomed...

INTRODUCTION Placenta can become an attractive source of stem cells due to its known richness in cell number and accessible, non-invasive procedures to harvest them. The purpose of this study focuses on the pluripotecy of placental-derived mesenchymal stem cells through differentiation towards osteogenic and neurogenic lineages. MATERIALS AND METHODS The biological material was represented by...

Background: Spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells ...

Objective(s): In this paper, we discussed natural agents with protective effects against stem cell senescence. Different complications have been observed due to stem cell senescence and the most important of them is “Aging”. Senescent cells have not normal function and their secretary inflammatory factors induce chronic inflammation in body which causes different patho...

The complexity of multiple sclerosis (MS) and the incompetence of a large number of promise treatments in MS urge us to plan new and more effective therapeutic approaches that aim to suppress ongoing autoimmune responses and induction of local endogenous regeneration. Emerging data propose that hematopoietic, mesenchymal and neural stem cells have the potential to restore self-tolerance, to pro...

objective(s): sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. the present study was designed to analyze the effect of sertoli cells in differentiation of mouse embryonic stem cells (mescs) to germ cells.   materials and methods: a fusion construct composed of a stra8 gene promoter and the coding region of enhanced green fluorescence pro...