In this study, the relationship between IL-1β [-31 C / T] gene polymorphisms in herniated lumbar disc is offered to be investigated. was amplified by PCR [Polymerase Chain Reaction] method. Polymorphic site cut with restriction enzyme Alu I and genotyping were performed. Fifteen subjects (15%) homozygous for C/C allele at -31 position of gene. Of remaining 85 subjects, 64 (64%) heterozygous C/T...

background: it has been reported that vitamin d has broad anti-inflammatory and immunomodulatory effects. objective: to evaluate the effects of vitamin d on the expression of il-27 and il-33 in a model of experimental autoimmune encephalomyelitis (eae). methods: eae was induced in c57bl/6 mice by immunization with myelin oligodendroglial glycoprotein mixed with complete freund's adjuvant. ...

Background and Purpose—Ischemic brain injury secondary to arterial occlusion is characterized by acute local inflammation, which involves accumulation of polymorphonuclear neutrophils (PMN). Factors that influence the recruitment of PMN could represent new therapeutic targets in acute stroke. In this prospective study we evaluated numbers of peripheral blood mononuclear cells (PBMC) expressing ...

The role of allergen in T-cell mediated IL-31 production and its relationship with clinical features atopic dermatitis (AD) is unknown. by T cells has been mainly analysed qRT-PCR intracellular flow cytometry polyclonal activated peripheral blood mononuclear a low number patients without association the clinic. We studied memory response to house dust mite (HDM) when cocultured autologous lesio...

BACKGROUND AND PURPOSE Ischemic brain injury secondary to arterial occlusion is characterized by acute local inflammation, which involves accumulation of polymorphonuclear neutrophils (PMN). Factors that influence the recruitment of PMN could represent new therapeutic targets in acute stroke. In this prospective study we evaluated numbers of peripheral blood mononuclear cells (PBMC) expressing ...

Several pretransplant factors, including CRP (C-reactive protein) levels, reflect the risk of complications after allogeneic stem cell transplantation. IL-6 induces CRP increase, and we therefore investigated the effects of pretransplant IL-6, soluble IL-6 receptors, IL-6 family cytokines and CRP serum levels on outcome for 100 consecutive allotransplant recipients. All patients had related don...

Objective: The main function of IL-12 is differentiation of naive T cells intoTh1 cells and TGF-β is a powerful immunoregulatory cytokine. The immunomodulatory and anti-inflammatory properties of ginger have also been reported in some studies. The aim of this study was to evaluate the effects of ginger extract on the expression of IL-12 and TGF-β in a model of experimental autoimmune encephalom...

Background: Interleukin (IL-6) and C-reactive protein (CRP) are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease. We evaluated the role of adding hydrocortisone to two different anesthetic regimens, on the level of IL-6, CRP and cortisol levels following breast cancer surgery. Patients and Methods: In this...

bakground: multiple sclerosis (ms) is a cd4+ t cell-mediated autoimmune disease affecting the central nervous system (cns). it was previously believed that th1 cells were pathogenic t cells in experimental autoimmune encephalomyelitis (eae). however, the functional role of th1 cells in eae has been reconsidered upon the discovery of il-17- producing t cells which are consider as dominant effect...