A sequential Monte Carlo method for estimating GARCH models subject to an unknown number of structural breaks is proposed. Particle filtering techniques allow for fast and efficient updates of posterior quantities and forecasts in real time. The method conveniently deals with the path dependence problem that arises in these types of models. The performance of the method is shown to work well us...

objective(s):the mechanism of hypothermia action of acetaminophen (apap) remains unclear even 125 years after its synthesis. acetaminophen produces hypothermia. the mechanism of this reduction in core body temperature is not clear but evidence shows that it is not dependent on opioid and cannabinoid receptors. because of strong documents about the roles of gaba and benzodiazepine receptors in h...

Abstract: Knowledge-based protein folding potentials have proven successful in the recent years. Based on statistics of observed interatomic distances, they generally encode pairwise contact information. In this study we present a method that derives multi-body contact potentials from measurements of surface areas using coarse-grained protein models. The measurements are made using a newly impl...

A method is presented for scoring the model quality of experimental and theoretical protein structures. The structural model to be evaluated is dissected into small fragments via a sliding window, where each fragment is represented by a vector of multiple – angles. The sliding window ranges in size from a length of 1–10 – pairs (3–12 residues). In this method, the conformation of each fragment ...

The paper outlines a bioinspired approach named "network nervous system" and methods of simulation of infrastructure attacks and protection mechanisms based on this approach. The protection mechanisms based on this approach consist of distributed procedures of information collection and processing, which coordinate the activities of the main devices of a computer network, identify attacks, and ...

Theories, experimental results and applications associated with hydrogen behavior in amorphous metals and alloys are reviewed. An emphasis is made on the potential use of these advanced materials for hydrogen storage technology. Therefore, several properties that are especially relevant for such applications are assessed. These include structural models for hydrogen occupancy, sorption characte...

Low-energy electron diffraction (LEED) has been used to determine the structural relaxations present at the (3 1 1) surface of copper. Two sets of intensity vs energy curves were measured for normal incidence for 14 beams over a total energy range of 1932 eV. These data were compared with intensities calculated with the layer doubling method for a range of structural models, the comparisons bei...