psychological disorders such as depression have more prevalence in inflammatory bowel disease patients and can exacerbate the clinical course of the disease, so anti-depressant therapy may have a potential to positively impact the disease course. on the other hand several antidepressant drugs have shown anti-inflammatory and immunomodulatory properties. thus, this study aimed to explore the ben...

Objective: Opuntia humifusa (O. humifusa) Raf. has been used for the prevention and treatment of rheumatoid arthritis, inflammation, and cancer. Our study was designed to unveil the anti-nociceptive and anti-inflammatory effects of the methanolic extract of O. humifusa Raf stem (OHS).  Material and Methods: The anti-nociceptive effect was measured by hot plate, acetic acid-induced writhing, and...

Objective: Diabetes mellitus Type 2 is one of the most widespread chronic metabolic diseases. In most cases, this type of diabetes is associated with alterations in levels of some inflammatory cytokines and hormones. Considering anti-inflammatory properties of plant extracts rich in ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E), anti-diabetic properties of these two well-known anti...

Introduction: Rosemary, Rosmarinus (R.) officinalis L. is a well-known plant with several useful properties such as analgesic, anti-inflammatory and anti-neurodegenerative. It has been used in folk medicine to alleviate rheumatic pain, stomachache and dysmenorrhea. Rosemary has several constituents such as rosmarinic acid which can be responsible for therapeutic properties been noted with rosem...

fibrates, as hypolipidemic drugs known as agonists of peroxisome proliferator-activated receptors, diminish inflammatory responses. studies have shown that incorporation of a silicon atom into a drug structure improves its pharmacological potency, modifies its selectivity toward a given target, or changes its metabolic rate, in addition to increasing the lipophilicity of the compounds. a silico...

this study evaluated the effects of mesobuthus eupeus (me) scorpion venom on inflammatory response following injection. additionally, the present study examined whether immunotherapy at specific time intervals would be effective on inflammatory response after me venom inoculation. animals were divided randomly into four groups: the first group received ld50 of venom and the second and third gro...

introduction: nasal polyps are benign prolapsed mucosal lesions which commonly arise from the paranasal sinuses and lateral walls of the nose especially the contact areas of osteomeatal complex. though nasal polyps arising from the nasal septum have been reported, those arising from its anterior part are extremely rare and present a diagnostic dilemma.  aetiology is multifactorial and is mainly...

anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. in this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory disease...

introduction: knee osteoarthrosis is one of the most debilitating diseases. prolotherapy includes intraarticular injection of various drugs to decrease inflammation. injection of intradiscal o2-o3 has reduced pain and disability of patients with low back pain due to prolapsed lumbar disk. objective: to compare the effect of intraarticular injection of ozone and steroids in improvement of clinic...