BACKGROUND Increasing evidence has shown that tumor initiation and growth are nourished by a small subpopulation of cancer stem cells (CSCs) within the tumor mass. CSCs are posited to be responsible for tumor maintenance, growth, distant metastasis, and relapse after curative operation. We examined the expression of CSC markers in paraffin-embedded tissue sections of hepatocellular carcinoma (H...

Hair loss and thinning result from premature catagen telogen development, terminal to vellus conversion, the latter caused also by reduced bulge hair follicle stem cell (HFSC) number or ability produce progeny. Although it is known that nutraceutical supplementation with collagen peptides can improve skin physiology, of type XVII leads depletion HFSCs in mice, effect on HF biology remains elusi...

based on principal component analysis (pca), gge biplot analysis is an effective method to fully assess multienvironmental yield trials (mets). additive main effects and multiplicative interaction (ammi) is an alternative method for assessing phenotypic stability and adaptability. in this research, met data of 14 maize inbred lines were used to perform ammi and gge biplot analyses. these genoty...

Adult mammalian epidermis contains multiple stem cell populations in which quiescent and more proliferative stem and progenitor populations coexist. However, the precise interrelation of these populations in homeostasis remains unclear. Here, we blocked the contribution of quiescent keratin 19 (K19)-expressing bulge stem cells to hair follicle formation through genetic ablation of the essential...

In skeletal muscle fibers, forces must be transmitted between the plasma membrane and the intracellular contractile lattice, and within this lattice between adjacent myofibrils. Based on their prevalence, biomechanical properties and localization, desmin and keratin intermediate filaments (IFs) are likely to participate in structural connectivity and force transmission. We examined the passive ...