background chronic allograft nephropathy(can)  is one of the most common causes of chronic and end stage renal disease. it  is defined with mainly tubular atrophy and  interstitial fibrosis and no evidence of any other etiology, or functional disorder that caused at least three months after transplantation . control of risk factors (htn,dm,hlp, …) and limiting  usage of calcineurin inhibitors o...

how to cite this article: : farivar s, mohamadzade z, shiari r, fahimzad ar. neural differentiation of human umbilical cord mesenchymal stem cells by cerebrospinal fluid. . iran j child neurol. 2015 winter; 9(1):87-93.     abstract objective wharton’s jelly (wj) is the gelatinous connective tissue from the umbilical cord. it is composed of mesenchymal stem cells, collagen fibers, and proteoglyc...

Introduction: Mechanical stimulation of human mesenchymal stem cells has demonstrated changes in many cell behaviours such as adhesion, migration, growth and differentiation through mechanotransductive pathways. These include experiments on effect of nanotopography 1, shear stress, stiffness of extracellular matrix 2, strain, stress and acoustic wave energy 3 on cells. In this research we wer...

background: mesenchymal stem cells (mscs) are multipotent cells, capable of differentiating into different cell lines.they can sense their surrounding biochemical and biophysical factors, which play major roles in their differentiation toward different phenotypes. therefore, the exposure of these cells to endothelial growth factor (vegf) as well as hemodynamic biomechanical forces, which act on...

Background: Several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (MSCs) in allogeneic or mitogenic interactions. Cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. Objective: To investigate if adipose derived MSCs could inhibit Jurkat lym-phoblastic leukemia T cell proliferation during coculture. Me...

objective(s):the mesenchymal stem cells (mscs) have been introduced as appropriate cells for tissue engineering and medical applications. some studies have shown that topography of materials especially physical surface characteristics and particles size could enhance adhesion and proliferation of osteoblasts. in the present research, we studied the distinction effect of 30 and 60 μg/ml of zinc ...

Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system that may lead to disability of the patient. Current MS treatment regimens are still insufficient and research is conducted for developing more effective therapies capable of targeting neurodegeneration, inflammation, and demyelination. Recent results of experimental and clinical studies in ...

conclusions our data suggest that preconditioning with 5 μm h2o2 + 0.5% fbs and 10 μm h2o2 + 5% fbs improved cell proliferation and viability. however, the mechanisms related to protective properties of preconditioning and using this strategy in stem cell therapy requires more research. background mesenchymal stem cells (mscs) survival decreased following in vivo injection and its application h...