نتایج جستجو برای: talalay method
تعداد نتایج: 1630168 فیلتر نتایج به سال:
مقدمه: اندازه گیری فشار خون نوزادان برای بررسی سیستم قلبی – عروقی ایشان لازم است در حالیکه این اندازه گیری به ندرت انجام می شود که شاید ناشی از احتمال کم ابتلای نوزاد به اختلالات فشار خون و عدم وجود مرزبندی های مشخص در خصوص این اختلالات در نوزادان می باشد. از آنجا که در کشور ما روشهای معمول اندازه گیری فشار خون نوزادان بصورت non – invasive در مراکز مرجع اطفال و نوزادان شامل روشهای سنتی مثل flus...
Combining poxvirus-based immunotherapies which “step on the gas” to activate tumor antigen-specific T cell immune responses with immune checkpoint inhibitors (ICIs) which “release the brakes” on the immune system is a promising direction for enhancing cancer immunotherapy. Evidence for the potential clinical benefit from combination immunotherapy was obtained in a Phase I dose escalation trial....
Autologous stem cell transplantation using cryopreserved bone marrow offers the opportunity to rescue patients from hematopoietic toxicity caused by intensive chemotherapy. This approach is potentially useful for high-risk leukemias as well as for other cancers. The development of suitable methods for purging malignant cells from the bone marrow will offer a better chance of success for autolog...
Background The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC) is limited by adaptive activation of cell survival signals. We hypothesized that both signal transducer and activator of transcription 3 (STAT3) and Src-YES-associated protein 1 (YAP1) signaling are dually activated during EGFR TKI treatment to l...
PURPOSE Novel therapeutic regimens are needed to improve the dismal outcomes of patients with anaplastic thyroid cancer (ATC). Oncolytic herpes simplex virus have shown promising activity against human ATC. We studied the application of oncolytic herpes simplex virus (G207 and NV1023) in combination with currently used chemotherapeutic drugs (paclitaxel and doxorubicin) for the treatment of ATC...
Recent studies suggest the possibility of a direct antiangiogenic effect of anti-epidermal growth factor receptor (EGFR) drugs due to the presence of EGFR on endothelial cells. The aim of this study was to analyze the direct effect on endothelial cells of associating EGFR targeting, vascular endothelial growth factor receptor (VEGFR)-2 targeting, and irradiation. We examined both the cytotoxic ...
PM01183 is a novel marine-derived covalent DNA binder in clinical development. PM01183 is structurally similar to trabectedin (yondelis, ecteinascidin-743) except for the C subunit, and this modification is accompanied by different pharmacokinetics in cancer patients. We here characterize the interaction of PM01183 with the nucleotide excision repair (NER) pathway in comparison with trabectedin...
To investigate the possibility that anticancer drugs combined with cytokines may show increased activity, human tumor cells were treated with combinations of human recombinant interleukin 1 alpha (rIL-1 alpha) and etoposide (VP-16). The cytotoxicity of these combinations was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay using rIL-1 alpha-sensitive A375-C6 ...
The effects of vincristine (VCR) in combination with methotrexate (MTX) and other antitumor agents were evaluated by cell growth inhibition assay using a human acute lymphoblastic leukemia cell line (MOLT-3). The data were analyzed with the aid of an isobologram using the concept of an envelope of additivity (G. G. Steel and M. J. Peckman, Int. J. Radiat. Oncol., 5:85-91, 1979). Simultaneous ex...
بررسی وجود و چندگانگی جوابهای معادلات دیفرانسیل به ویژه با شرایط مرزی اغلب بسی دشوار بوده و همراه با گام های ملالت آور می باشد بطوریکه همواره نیاز به پیش شرط هایی می باشد که معادلات دیفرانسیل با شرایط مرزی مورد نظر باید داشته باشد. بنابراین اثبات آنالیزی وجود و چندگانگی جوابهای مسائل مقدار مرزی غیر خطی اغلب غیر ممکن می باشد. روشهای تقریبی- تحلیلی یا روشهای عددی صرفاً برای بدست آوردن جواب موجود ...
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