During early development of the mammalian cerebral cortex, young neurons migrate outward from the site of their final mitosis in the ventricular zone into the cortical plate, where they form the adult cortex. Time-lapse confocal microscopy was used to observe directly the dynamic behaviors of migrating cells in living slices of developing cortex. The majority of cells migrated along a radial pa...

Correspondence To the Editor: A 73‑year‑old man presented to Department of Cardiology at Xinhua Hospital, Shanghai Jiaotong University School of Medicine with a history of anterior wall myocardial infarction (MI) and multimorphic ventricular tachycardia (VT) in approximately September 2013. His VT burden became progressive increase despite treatment with percutaneous coronary intervention (PCI)...

The diverse array of neurons and glia in the mammalian cerebral cortex arises from proliferating cells of the ventricular zone that surrounds the lateral ventricles of the developing brain. A fundamental but unresolved question is whether the individual cells of the ventricular zone are committed to producing progeny of only one particular phenotype or whether they generate progeny of more than...

in this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. eighty male wistar rats were divided into two series (n = 8 in each group). in the first series, all groups (except the control (con) group) ...

background: early diagnosis of left ventricular mass (lvm) inappropriateness and left ventricular hypertrophy   (lvh) can result in preventing diastolic left ventricular dysfunction and its related morbidity and mortality. this study was performed to determine if diastolic dysfunction   is associated with lvh and inappropriate lvm. methods: one hundred   and twenty five uncomplicated hypertensi...

Neocortical neuronogenesis occurs in the pseudostratified ventricular epithelium (PVE) where nuclei of proliferative cells undergo interkinetic nuclear movement. A fraction of daughter cells exits the cell cycle as neurons (the quiescent, or Q, fraction), whereas a complementary fraction remains in the cell cycle (the proliferative, or P, fraction). By means of sequential thymidine and bromodeo...

Recent loss-of-function studies highlight the importance of the transcription factor GATA4 in the myocardial response to injury in the adult heart. However, the potential effects of gain-in-function of GATA4 overexpression, and transcription factors in general, is hindered by the fact that transcription factors are neither secreted nor taken up by cells. Chimeric proteins incorporating motifs o...

The programming of implantable cardioverter-defibrillators (ICDs) influences inappropriate shock rates. The aim of the study is to analyse rates of patients with appropriate and inappropriate shocks according to detection zones in the OPTION trial. All patients received dual chamber (DC) ICDs randomly assigned to be programmed either to single chamber (SC) or to DC settings including PARAD+ alg...