Prokineticin receptors, PKR1 and PKR2 (provisional nomenclature as recommended by NC-IUPHAR [26]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (also known endocrine gland-derived vascular endothelial growth factor, mambakine) prokineticin-2 (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, intestinal toxin 1 (MIT1, [71]) is ...

background: the metabolically active tumor cells may be characterized by a pronounced adenosine release that regulates the growth and development of the tumor. consequently, the expression pattern of defined receptor subtypes will be an important determinant for specific effects of adenosine on the control of tumor cell growth. in recent studies, the expression profile, signal transduction, mol...

meningiomas are slow-growing neoplasms which recur locally, their morphologic grading is simple but do not always correlate with patient outcome. the aim of present study is to evaluate the status of progesterone receptor (pr) and proliferation marker ki67 in various grades of meningioma in a group of iranian patients. 78 cases of meningioma were selected from the file of a hospital university....

introduction: in this study, the effect of memantine administration into the nucleus accumbens on the metabolic changes induced by acute stress in female mice was evaluated. methods: intra-accumbens unilateral or bilateral canulation was performed. one week after recovery, a group of animals were given memantine (1, 0.5, and 0.1 μg/mouse) five min before stress induction intra-accumbally, and t...

introduction: dopamine plays an important role in the central nervous system for modulating food intake. dopamine receptors are distributed within the hypothalamus, and expression of d1 receptors is significant in hypothalamic paraventricular nucleus (pvn). therefore, the aim of this study was to find if pvn-microinjected skf38393, d1 receptor agonist, may modulate food intake. methods: guide c...

The novel coronavirus disease 2019 (COVID-19) is highly contagious caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 infections are usually associated with symptoms along fever, myalgia, fatigue, altered taste and smell sensation. However, some oral cavity manifestations have been found in patients. There debate whether these due to SARS-CoV-2 infection or seconda...

Abstract FERONIA (FER) is a member of the Catharanthus roseus receptor-like kinase 1-like (CrRLK1L) protein subfamily, which participates in reproduction, abiotic stress, biotic cell growth, hormone response, and other molecular mechanisms plants. However, mechanism by single RLK capable mediating multiple signals activating cellular responses remains unclear. Here, we summarize research progre...

Several stimuli can change maternal hormone levels during pregnancy. These changes may affect trophoblastic cells and modulate the development of embryo placental tissue itself. Changes in cortisol are associated with impaired trophoblast implantation function, addition to other pregnancy complications. This study aims analyze effects low high doses on an extravillous cell line, various exposur...