AIMS One of the main limitations for an effective cell therapy for the heart is the poor cell engraftment after implantation, which is partly due to a large percentage of cell death in the hostile myocardium. In the present study, we investigated the utilization of necrostatin-1 (Nec-1) as a possible attenuator of cell death in cardiomyocyte progenitor cells (CMPCs). METHODS AND RESULTS In a ...

Immunological tolerance to a soluble, partially purified fraction of histocompatibility (H)-2(a) antigen was induced in B10.D2 strain mice. The fraction used was obtained after chromatography on a Sephadex G-150 column. Tolerance of humoral-antibody formation (cytotoxins and hemagglutinins) was observed in mice injected with soluble antigen since birth, but cell-mediated immunity, as measured b...

Six human melanoma xenograft lines have been established in athymic mice from metastatic lesions in six different patients. Permanent cell lines in monolayer culture have been established from four of the xenograft lines. The cellular radiation sensitivity of the donor patients' tumors, the xenograft lines, and the cell lines were measured in vitro. The Courtenay soft agar colony assay was used...

Although melanoma progression and staging is clinically well characterized, a large variation is observed in pathogenesis, progression, and therapeutic responses. Clearly, intrinsic characteristics of melanoma cells contribute to this variety. An important factor, in both progression of the disease and response to therapy, is the tumor-associated vasculature. We postulate that melanoma cells co...

BACKGROUND BRCC3 has been found to be aberrantly expressed in breast tumors and involved in DNA damage response. The contribution of BRCC3 to nasopharyngeal carcinoma prognosis and radiosensitivity is still unclear. METHODS Immunohistochemical analysis of BRCC3 was carried out in 100 nasopharyngeal carcinoma tissues, and the protein level was correlated to patient survival. BRCC3 expression o...

to evaluate the effect of adding neoadjuvant chemotherapy to surgery and radiation therapy for locally advanced resectable oral cavity squamous cell carcinoma, 24 patients with t3 or t4a oral cavity squamous cell carcinoma were randomly assigned to surgery alone or docetaxel, cisplatin, and 5-fu (tpf) induction chemotherapy followed by surgery. all patients were planned to receive chemoradiothe...

purpose: to investigate the outcomes of keratolimbal allograft (klal) for treatment of total limbal stem cell deficiency (lscd). method: patients with total lscd and adequate tear production were included. a total of 27 klal procedures were performed in 21 eyes of 20 patients with lscd. immunosuppression was achived using mycophenolate and cyclosporine. main outcome measure was improvement in v...

Salvia chorassanica Bunge is one of the Iranian endemic species of Salvia. There is not any reported literature on S. chorassanica. This study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of S. chorassanica and its fractions on HeLa cell line. Cells were cultured in EX-CELL®, an animal free medium specially designed for HeLa cell line ...