Aspirin eugenol ester (AEE) is a promising drug candidate, which is used for the treatment of inflammation, pain and fever and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to inflammation and thrombosis, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidona...

The purpose of this study was to evaluate the histopathological effects of eugenol (EUG) and iso-eugenol (IsoEUG)--with or without visible light (VL) irradiation--on oral mucous membranes. Oral mucous membranes of mice were applied with three agents, EUG, IsoEUG, and aceton (as the control) in the absence or presence of VL irradiation. VL irradiation resulted in more tissue damage for EUG- or I...

BACKGROUND Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several classes of organic compounds. RESULTS Bismuth nitrate pentahydrate-induced nitration of eugenol has...

Molecular docking and quantum chemistry calculations were used to establish the molecular model of β-cyclodextrin inclusion complex with five major compounds found in Thai sweet basil (Ocimum basilicum) essential oils, which includes linalool, eugenol, methyl eugenol, estragole, and eucalyptol. The electronic structures and the binding energies of 1:1 inclusion complexes of host:guest ratio for...

Background: Arsenic trioxide (As2O3) has shown effectiveness in the treatment of leukemia, but it is also associated with hepatotoxicity. Given antileukemic drug-induced oxidative stress and toxicity, this study focused on the mitigatory role of eugenol, a monoterpene compound from clove oil, in the hepatic tissue of Wistar rats.Methods: Twenty-four male Wistar rats (180–250 g) were randomly di...

María E. Hidalgo* and Carlos De la Rosa Facultad de Ciencias, Universidad de Valparaíso, Gran Bretaña 1111, Valparaíso, Chile Héctor Carrasco, Wilson Cardona and Claudio Gallardo Facultad de Ecología y Recursos Naturales, Universidad Andrés Bello, Los Fresnos 52, Viña del Mar, Chile Luis Espinoza Departamento de Química, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso,...

In field trapping tests in Hungary cinnamyl alcohol (3-phenyl-2-propen-l-ol) and transanethole [(1-methoxy-4-(1-propenyl)benzene)] attracted significantly more adult Epicometis (Tropinota) hirta (Coleoptera, Scarabaeidae, Cetoniinae) when presented together in the same bait compared to the single compounds Best attraction was recorded by a 1:1 mixture. Addition of other common floral scent comp...

O presente projeto procurou produzir produtos semi-sintéticos orgânicospreferencialmente que possuam atividade biológica, através de reações click,utilizando como composto partida o timol, carvarol e eugenol. Os compostos estãopresentes nos óleos essenciais extraídos do orégano ( Origanum Vulgare ) tanto parao quanto carvacrol cravo da índia Eugenia caryophyllata para Osderivados foram produzid...