Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.Due to changes in the expression of these proteins...

background: it has been proposed that oxidative stress may contribute to the development of testicular abnormalities in diabetes. morus alba leaf extract (mae) has hypoglycemic and antioxidant properties. we, therefore, explored the impact of the administration of mae on steroidogenesis in diabetic rats. methods: to address this hypothesis, we measured the serum level of glucose, insulin, and f...

conclusions the identified expression profiles of some examined mirnas might offer important points to consider for the treatment of naive patients and the management of chronically infected hcv patients in egypt and around the world. results our results revealed differential expression levels of the analyzed mirnas compared to the normal controls. twenty-seven mirnas (including mir-105, mir-14...

Objective(s): Diabetic cardiomyopathy is a leading factor of high morbidity and mortality in diabetic patients. Our previous results revealed that ginkgolide B alleviates endothelial dysfunction in diabetic rats. This study aimed to investigate the effect of ginkgolide B on cardiac dysfunction and its mechanism in diabetic rats.Materials and Methods:<...

background: hoxa11 and hoxa10 are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. the expression of these genes is decreased in women with myomas. objective: to determine whether myomectomy would reverse hoxa11 and hoxa10 expression, we evaluated the transcript levels of these genes in the endometria o...

hydrogen sulfide (h2s) has been shown to protect the gastric mucosa through several protective mechanisms but till now its effect on mrna expression of sodium bicarbonate cotransporter 1 (nbc1), trefoil factor1 (tff1) and trefoil factor2 (tff2) was not investigated. this study was aimed to evaluate the effect of h2s on mrna expression of nbc1, tff1 and tff2 in rat gastric mucosa in response to ...

Objective(s):  Apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. Because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), in present study we studied the apoptosis in T lymphocytes from Iranian SLE patientsat protein and gene expression levels for some molecules which are involved in apopt...

Background: A possible mechanism by which hyperthermia enhances tumor immunogenicity is the induction of NKG2D ligands on tumor cells. Although the expression of MHC class I chain-related protein A and B (MICA/B) has previously been reported in different carcinomas, there is no information about MICA/B expression in liposarcomas. Objective: To investigate MICA/B induction in a human liposarcoma...

Background: Toll like receptors (TLRs) are well recognized players in inflammatory conditions. Among them TLR-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. Objective: The present study was aimed to examine the effects of percutanoeus coronary intervention (PCI) as a revascularization method on monocyte expression of hTLR-4 and on the serum levels ...