Human T-lymphotropic virus-type 1 (HTLV-1) is the etiologic agent of the neurologic disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Tax viral protein plays a critical role in viral pathogenesis. Previous studies suggested that extracellular Tax might involve cytokine-like extracellular effects. We evaluated Tax secretion in 18 h-ex vivo peripheral blood mononuclear ...

Most individuals infected with human T lymphocyte virus (HTLV) type 1 or 2 will not develop the disease related to this virus, remaining asymptomatic for the rest of their lives. This fact has important implications for prospective counseling and evaluation of this population. Individuals infected with this virus, once identified, should be submitted to anamnesis and complete physical examinati...

The aim of the present paper is to formulate two new mathematical models describe co-dynamics severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human T-cell lymphotropic virus type-I (HTLV-I) in a host. characterizes interplaying between seven compartments, uninfected ECs, latently SARS-CoV-2-infected actively free SARS-CoV-2 particles, CD4+T cells, HTLV-I-infected cells cells. i...

Human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a disease that is clinically characterized by unremitting myelopathic symptoms, such as spastic paraparesis, lower back pain, bladder dysfunction, and mild sensory disorders of the limbs, which are symmetrical in most patients1. HTLV-I infection is a necessary condition for the develo...

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) remains a challenging disease. Treatment options are scarce, and their safety and efficacy are currently a matter of concern. We present a case report describing our experience using cyclosporine in a patient with early HAM/TSP who started with a gait disturbance at Vall d’Hebron University Hospital (Barcelona) from August 2012...

BACKGROUND indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas. OBJECTIVES (a) to define the prevalence of indeterminate WB among different populations from Argentina; (b) to evaluate if low proviral load (PVL) is associated with indeterminate WB profiles; and (c) to describe mutatio...

Serum concentrations of soluble interleukin 2 receptors (sIL 2R) were measured by an enzyme-linked immunosorbent assay (ELISA) in 30 patients with adult T cell leukemia (ATL), in 9 patients with other hematopoietic malignancies, and in 17 asymptomatic individuals seropositive for human T cell leukemia virus type I (HTLV-I). Sixty HTLV-I seronegative, age-matched controls showed a normal range o...

HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) develops in a subset of human T lymphotropic virus type I (HTLV-I)–infected individuals.1 Its evolution is chronic and progressive, without remission.2 Recently, a study using a histone deacetylase inhibitor reported, for the first time, a spectacular decline in the HTLV-I proviral load in a series of HAM/TSP patients.3 Unfortu...

Desde o descobrimento e caracterização do retrovírus (HTLV-i) a sua associação com algumas neoplasias de células T periféricas, muitos avanços foram alcançados quanto aos aspectos etiopatológicos da leucemia/linfoma adulto (LLTA). Estudos soroepidemiológicos anti-HTLV-I realizados em diversas partes mundo demonstraram que: HTLV-I é agente etiológico LLTA paraparesia espástica tropical (TSP); te...