Abstract Individualist normative theories appear inadequate for the complex moral challenges of climate change. In ethics, this is especially notable with relative marginalization Kant. I argue that Kant’s philosophy, understood through its historical and cosmopolitan dimensions, has untapped potential crisis. First, situate Kant in ethics evaluate his due to perceived individualism, interiorit...

Kant discovered a philosophical problem with mathematical proof. Despite being a priori, its methodology involves more than analytic truth. But what else is involved? This problem is widely taken to have been solved by Frege’s extension of logic beyond its restricted (and largely Aristotelian) form. Nevertheless, a successor problem remains: both traditional and contemporary (classical) mathema...

At the very end of the Transcendental Analytic Kant argues that the two concepts something/possible and nothing/impossible, which constitute the starting point of traditional ontology, are not in fact the highest concepts. Instead, these two opposed concepts stand under a higher concept, namely the concept of an object in general, and result from that concept’s division. Both the concept of so...

Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action. In vitro, CGP 29 287 is a potent inhibitor of primate plasma renin (inhibitory concentration, 50%: human = 1 X 10(-9) M; marmoset = 5 X 10(-9) M) and less potent against dog (2 X 10(-7) M) or rat (3 X 10(-5) M) plasma ren...

Pdr5p, the major multidrug exporter in Saccharomyces cerevisiae, is a member of the ATP-binding cassette (ABC) superfamily. Pdr5p shares similar mechanisms of substrate recognition and transport with the human MDR1-Pgp, despite an inverted topology of transmembrane and ATP-binding domains. The hexahistidine-tagged Pdr5p multidrug transporter was highly overexpressed in yeast strains where other...