The conversion of isobutanol to light olefins over zeolites was investigated by IR operando spectroscopy. FER showed a surprisingly high selectivity for the direct iso-butanol linear butenes, hence catalyzing dehydration and skeletal isomerization in one step. As fundamental understanding separate reactions is required design superior catalysts, an in-situ FT-IR mechanistic study reaction carri...

Tissue sensitivity to exogenous insulin was determined in 10 obese diabetic patients, in 15 patients with simple obesity, and in 28 non·obese controls. Eight of the obese diabetics and five of the patients with simple obesity underwent dietary restriction (1,000-1,600 kcal/day) and physical training for eight weeks. Insulin sensitivity was evaluated by the euglycemic insulin clamp technique for...

PURPOSE AND EXPERIMENTAL DESIGN The mutational spectrum of MADH4 (DPC4/SMAD4) opens valuable insights into the functions of this protein that confer its tumor-suppressive nature in human tumors. We present the MADH4 genetic status determined on a new set of pancreatic, biliary, and duodenal cancers with comparison to the mutational data reported for various tumor types. RESULTS Homozygous del...

Several innovative filtration technologies have been developed in the last two decades to decrease the backwash requirements, to increase the water production efficiency, and to improve the operational and design conditions. The Compressible Medium Filter (CMF) also known as the “Fuzzy Filter” involves the use of a synthetic compressible fiber (polyvaniladene) porous material as the filtering m...

Agouti-related protein (Agrp), one of the two naturally occurring inverse agonists known to inhibit G protein-coupled receptor activity, regulates energy expenditure by decreasing basal and blocking agonist-promoted melanocortin receptor (MCR) signaling. Here we report that, in addition to its inverse agonistic activities, Agrp exhibits agonistic properties on the endocytosis pathway of melanoc...

Disruptions of the melanocortin signaling system have been linked to obesity. We investigated a possible role of the central nervous melanocortin system (CNS-Mcr) in the control of adiposity through effects on nutrient partitioning and cellular lipid metabolism independent of nutrient intake. We report that pharmacological inhibition of melanocortin receptors (Mcr) in rats and genetic disruptio...

To test the hypothesis that insulin acutely enhances the metabolic clearance rate (MCR) of dehydroepiandrosterone in humans, the effect of a short-term insulin infusion on the MCR of dehydroepiandrosterone was assessed in 10 men and 7 women. After an overnight fast, dehydroepiandrosterone was infused at 3.47 mumol/h for 6.5 h. At 240 min, a hyperinsulinemic-euglycemic clamp was begun by infusin...