Cancer cells secrete VEGF, which plays a key role in their growth, invasion, extravasation and metastasis. Direct cancer cell-endothelial cell interaction, mediated by gap junctions, is of critical importance in the extravasation process. In this study, we evaluated avastin (Av), an anti-VEGF antibody; and oleamide (OL), a gap junction inhibitor, using MDA-MB-231 human breast cancer cells in vi...

Abstract Background and Objective: It has been shown that oxidative stress increases in diabetes and it has an important role in its development and subsequent complications. Thus, the aim of this study was to investigate the effect of acute resistance exercise on oxidative stress in skeletal muscle and cardiac tissues of streptozotocin-induced diabetic rats. Materials and Methods: Twenty male ...

BACKGROUND Minimal deviation adenocarcinoma (MDA) of the uterine cervix is defined as an extremely well differentiated variant of cervical adenocarcinoma, with well-formed glands that resemble benign glands but show distinct nuclear anaplasia or evidence of stromal invasion. Thus, MDA is difficult to differentiate from other cervical hyperplastic lesions. Monoclonality is a major characteristic...

We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces) activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced (GSH) in male rats exposed bisphenol A (BPA). Adult Wistar albino were divided into 4 groups as follows (n = 7/group): control, BPA, BPA+Black carrot. Testicular Ces, MDA, GST GSH analyzed by using a spectrophotometer system....

The Object Management Group (OMG) is promoting the Model Driven Architecture (MDA) approach to support interaction among enterprises based on business process models. Based on this approach, we discuss in this paper how to specify performance indicators among the levels with different degree of abstraction suggested in MDA. These indicators will drive the monitoring activities to check the exec...

We present the design and preliminary results of the validation of the Player Experience Inventory (PXI). Based on the input of 64 experts in the field of playercomputer interaction, we designed and refined this new scale. Our scale is based on the MDA framework (and on Means-End theory, underlying MDA). The PXI incorporates two subscales, one with dimensions at the functional level (i.e., dyna...

Background: Among the non-surgical methods of preventing conception, taking oral contraceptive pills is the most common way. Some of the studies have shown that contraceptive pills due to containing estrogen and progesterone cause lipid peroxidation and as a consequence increase the level of oxidative stress. Aim: To compare the level of plasma Malone dialdehide in LD contraceptive pill and con...

Serum levels of glutathione reductase (GR), glutathione S-transferase-alpha (GST-alpha) and malondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. Except for level of GR in patients with HBV, GR, GST-alpha and MDA were raised significantly in patients compared with controls. At 100% specificity, the sensitivity of the 3...

BACKGROUND Infertility is defined as the inability to achieve the pregnancy within a year of unprotected intercourse. Infertility is a complex issue and different factors such as stress oxidative can be involved in this problem. So, any attempt to neutralize oxidative stress would be helpful in the treatment of infertility. Melatonin is a known scavenger of free radicals. OBJECTIVE The aim of...

This experimental study was designed to determine effects of Nigella sativa oil (NSO) on endothelin-1 (ET-1) level and oxidative stress parameters, superoxide dismutase (SOD) and malondialdehyde (MDA) in a rat sepsis model. Twenty four adult Wistar albino rats were divided randomly into three groups: sham group (group 1), sepsis group (group 2), sepsis group pretreated with NSO (group 3). Serum...