نتایج جستجو برای: passive avoidance learning
تعداد نتایج: 701123 فیلتر نتایج به سال:
Background and Objective: Insulin regulates many important processes in the central nervous system such as synaptic plasticity, learning and memory. Experimental evidence suggest a link between type 2 diabetes and Alzheimer’s disease (AD). Insulin modulates the metabolism of beta-amyloid precursor protein in neurons, decreasing the intracellular accumulation of beta-amyloid. The aim of...
Abstract Introduction: Diabetes mellitus accompanies with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Considering the beneficial antidiabetic potential of Apium graveolens (AG ), this research study was conducted to evaluate the effect of chronic i.p. administration of AG on learning and memory in diabetic rats using passive avoidanc...
Introduction: Long-term stress disturbs HPA axis and increases glucocorticoids release, which disturbs neural plasticity in the hippocampus and may lead to learning and memory deficits. Noticeably, vitamin D plays a protective role in the nervous system and has receptors in the hippocampus. This behavioral study investigates the possible protective role of vitamin-D against the negative effects...
Introduction & Objective: Diabetes mellitus (especially type I) is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Considering the potential anti-diabetic effect of the medicinal plant Withania somnifera (ashwagandha) and the augmenting effect of its consumption on the memory and mental health, this study was conducted to ev...
Methods: For this purpose, rats were injected with ICV STZ bilaterally, on days 1 and 3 (3 mg/kg). The STZ-injected rats received GEN (1 mg/kg/day, p.o.) starting one day pre-surgery for two weeks. The learning and memory performance was assessed using passive avoidance paradigm, and for spatial cognition evaluation, radial eight-arm maze (RAM) task was used. Results: It was found out that GEN-...
Proteome Analysis of Rat Hippocampus Following Morphine-induced Amnesia and State-dependent Learning
Morphine's effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. Whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. The present study intended to investigate whether administration of morphine ...
introduction: learning and memory deficits in some diseases are new subjects of research. bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. this study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. methods: adult male wist...
Background: The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L. extract in learning and memory processes has been proposed. In the present study, the effect of crocins on sporadic Alzheimer's disease induced by intracerebroventricular (icv) streptozocin (STZ) in male rats was investigated. Methods: Male adult Wistar rats (n = 90 and 260-...
This study examined behavioral effects mediated by NMDA (N-methyl-D-aspartic acid) receptors in 12-week streptozotocin (STZ)-induced diabetic rats. Effects of an NMDA receptor agonist on behavior in the open field test, passive avoidance test and T-maze were examined in control groups of rats and in rats with diabetes mellitus (DM). We have used 116 rats for experiments. Experimental type I dia...
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