Platinum therapies For half a century, the field of metalbased anticancer drugs has been dominated by the precious metal platinum. The discovery of platinum’s anticancer properties was made by chance during an experiment in 1965, conducted at Michigan State University by Barnett Rosenberg. Rosenberg used a platinum electrode to apply an electric field to a colony of E. coli, which was observed ...

OBJECTIVE Isotope ratio mass spectrometry of hydrogen and oxygen is frequently used to determine total energy expenditure (TEE) using doubly labeled water. Conventionally, hydrogen isotope ratio is determined in hydrogen gas generated from water samples using zinc reduction. We compare this with a new automated platinum method to determine the ratios of hydrogen isotopes in deuterium-enriched w...

We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for (1) cell models of acquired drug resistance reporting platinum and taxane sensitivities and (2) clinical trials of platinum or taxane salvage therapy in ovarian cancer. One hundred and thirty-seven models of acqu...

Despite the high objective response rate (70–80%) of advanced epithelial ovarian cancer to platinum-/taxane-based chemotherapy the majority of patients treated for this condition ultimately experience recurrence of the disease process [1–3]. At the time of documented progression of the malignancy, these individuals are candidates to receive a second-line management strategy. It is well recogniz...

BACKGROUND AND PURPOSE Novel stratagems to improve the efficacy of platinum coils in occluding cerebral aneurysms have primarily involved coating coils with materials thought likely to provoke more desirable histologic reactions. No investigations to date, however, have evaluated the utility of gold or vitronectin coatings, despite known endovascular histologic effects of these agents, which ma...

infiltration is a complex process that changed by initial moisture and water head on the soil surface. the main objective of this study was to estimate the coefficients of infiltration equations, kostiakov-lewis, philip and horton, and evaluate the sensitivity of these equations and their coefficients under various initial conditions (initial moisture soil) and boundary (water head on soil surf...

BACKGROUND Although the platinum regimen is adopted widely nowadays in spite of the excessive side effects, there is still no international standard for palliative chemotherapy of advanced gastric cancer. This meta-analysis assessed the efficacy and tolerability of platinum versus non-platinum chemotherapy as first-line palliative treatment in patients with inoperable, advanced gastric cancer. ...

Nickel base superalloy alloys are used in the manufacture of gas turbine engine components, which in use are exposed to high temperatures and corrosive environments. The platinum aluminide coatings described here have been developed to protect nickel base superalloy alloys from oxidation. In this study, the effect of cyclic oxidation, platinum layer thickness and aluminizing process on beha...

the interactions between platinum complexes and human serum albumin (hsa) play crucial roles in the distribution, metabolism, and activity of platinum-based anticancer drugs. octahedral platinum (iv) complexes represent a significant class of anticancer agents that display molecular pharmacological properties different from cisplatin. in this study, the interaction between two pt(iv) complexes ...

this study was designed to assess the role of first-line chemotherapy with 5-fu and platinum in the treatment of advanced or recurrent cervical cancer, ten patients with advanced or recurrent cancer of the cervix, with no prior chemotherapy were entered in phase ii trial, from oct. 2000 to nov. 2001. eight patients were treated with cis-platinum (50 mg/m2 over 60 minutes in first day) followed ...