KIT and / or PDGFRA activation mutation is the initial molecular event of gastrointestinal stromal tumor (GIST), mechanism leading to malignant progression GIST needs be further studied broken through. This study aims understand from perspective metabolic reprogramming provide a new target for treatment GIST. In present study, transcriptome metabolome were used test tissue adjacent normal sampl...

Mitochondrial sirtuins are NAD-dependent enzymes that bind and regulate numerous metabolic pathways within the mitochondria. For example, SIRT3 functions as an NAD-dependent deacetylase that binds and activates numerous oxidative pathways. We have discovered that sirtuins regulate metabolic pathways important in tumor cell metabolism. One hallmark feature of tumor cells is a shift from oxidativ...

Lipid metabolism is regulated by multiple signaling pathways, and generates a variety of bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules, such as fatty acid, eicosanoids, diacylglycerol, phosphatidic acid, lysophophatidic acid, ceramide, sphingosine, sphingosine-1-phosphate, phosphatidylinositol-3 phosphate, and cholesterol, are involved in the activation...

objective(s): although low-dose radiotherapy (rt) that involves low collateral damage is more suitable for hepatocellular carcinoma (hcc) than traditional high-dose rt, but to achieve satisfactory therapeutic effect with low-dose rt, it is necessary to sensitize hcc cells to irradiation. this study was aimed to determine whether radiosensitivity of hcc cells can be enhanced using mir-26b by tar...

PGC-1α is a transcription coactivator centrally involved in the regulation of energy balance and metabolism. A recent study in Cell Metabolism adds another role for Pgc-1α, namely gene regulation in mitochondrial maintenance and metabolic homeostasis. The latest findings indicate significant increases in levels of DNA methylation within the promoter region of the Pgc-1α gene within human skelet...