Background Combination immunotherapy is quickly gaining attention in the field of cancer treatment. IL-2, a cytokine which activates T cells, and ipilimumab, a monoclonal antibody that blocks CTLA-4, are both approved as monotherapy for metastatic melanoma. To date, combination immunotherapy with IL-2 and anti-CTLA-4 has not been adequately investigated. We hypothesized that that this combinati...

patients and methods this was a retrospective study including 207 consecutive patients who were enrolled using computerized hepatocellular carcinoma database consisting of 105 patients who underwent combined tace with rfa, and 102 patients who underwent tace alone with long-term follow-up. results the complete remission rate was meaningfully higher in the combination group (97.1%, 102/105) than...

In this paper, we propose a new general method to compute rigorously global smooth branches of equilibria of higher-dimensional partial differential equations. The theoretical framework is based on a combination of the theory introduced in Global smooth solution curves using rigorous branch following [2] and in Analytic estimates and rigorous continuation for equilibria of higher-dimensional PD...

A sound multi-species vegetation buffer design should incorporate the species that facilitate rapid degradation and sequestration of deposited herbicides in the buffer. A field lysimeter study with six different ground covers (bare ground, orchardgrass, tall fescue, timothy, smooth bromegrass, and switchgrass) was established to assess the bioremediation capacity of five forage species to enhan...

The radiorespirometric method was used to study the pathways of glucose metabolism in the rough and smooth variants of Bacillus stearothermophilus NCA 1518. The Embden-Meyerhof (EM) pathway was more active in the smooth variant than in the rough variant. The participation of the hexose monophosphate shunt (HMP) and EM pathways in the smooth variant was calculated as 4.2 and 95.8%, respectively....