A highly efficient, organocatalytic, enantioselective Strecker reaction of cyclic N-acyl ketimines was developed for the preparation of enantioenriched cyclic α-amino nitriles with a quaternary carbon stereocentre and anti-HIV drug DPC 083.

Abstract Current standard-of-care for glioblastoma (GBM) includes surgery followed by radiation with concurrent and adjuvant temozolomide. There are limited treatment options available upon progression or recurrence of disease. Options often involve participation in clinical trials promising new therapies. However, patients may not meet the strictly defined entry criteria to participate these t...

Lifelong competence development is a fundamental premise for an information society, as well as major aim and challenge. Facing the variety of learning programs and qualification measures, problems emerge in supporting lifelong learning. Efficient competence development necessitates providing learners with learning opportunities which are appropriate for their current knowledge and for their in...

Letter to: Vaginal Birth at Term – Part 1. Guideline of the DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No. 015/083, December 2020)Geburtshilfe Frauenheilkd 2022; 82(11): 1143-1193DOI: 10.1055/a-1904-6546

Quality assurance (QA) and continuing competence (CC) programs aim to ensure acceptable levels of health care provider competence, but it is unknown which program methods most successfully achieve this goal. The objectives of the study reported in this article were to compare two distinct QA/CC programs of Canadian dental hygienists and assess the impact of these two programs on practice behavi...