Horseradish peroxidase has been shown to catalyze the oxidation of veratryl alcohol (3,4-dimethoxybenzyl alcohol) and benzyl alcohol to the respective aldehydes in the presence of reduced glutathione, MnC12, and an organic acid metal chelator such as lactate. The oxidation is most likely the result of hydrogen abstraction from the benzylic carbon of the substrate alcohol leading to eventual dis...

The oxidation of hypersensitive radical probes by chloroperoxidase from Caldariomyces fumago (CPO) was studied in an attempt to "time" a putative radical intermediate. Oxidation of (trans-2-phenylcyclopropyl)methane, previously studied by Zaks and Dodds [Zaks, A., and Dodds, D. R. (1995) J. Am. Chem. Soc. 115, 10419-10424] was reinvestigated. Unrearranged oxidation products were found as previo...

People tend to equate the in vitro alcohol oxidation (via aldehyde to acid) with what happens in the animal body. However, the chemical experience shows, that the nature of the intermediate(s) and the yield of end product(s) varies with the organism studied. The animal has a peculiar oxidation ability: some substances are oxidized almost completely whereas for others the oxidation might be rest...

During a study of cyclic alcohol oxidation by a partially purified rat liver enzyme system (l), it was noted that ethanol was also oxidized by this preparation. Since the ratio of the rate of ethanol oxidation to the rate of cyclohexanol oxidation remained constant during purification, the possibility arose that the activity with cyclic substrates was due to the conventional alcohol dehydrogena...

Cell suspensions of Methylosinus trichosporium oxidized the aromatic alcohols benzyl alcohol, vanillyl alcohol, and veratryl alcohol to the corresponding aldehydes, and with the exception of vanillyl alcohol, the aldehydes were further oxidized to the corresponding aromatic acids. No other transformation was observed, and the methoxyl moieties attached to the aromatic nucleus remained intact. M...

Although many investigators have studied the effects of pyruvate and glucose on alcohol metabolism, there is still disagreement as to what effect. they have on the rate of alcohol oxidat.ion. Jacobsen (1) discussed t.he various reports in which the results vary from no effect of pyruvate, inhibition by pyruvate or glucose, or an actual increase in the rate of alcohol oxidation by pyruvate or gl...