BACKGROUND Factors contributing to the generation of soluble P- and E-selectins remain unclear. RESULTS This work demonstrates that mice lacking P-selectin glycoprotein ligand-1 (Psgl-1(-/-)) are deficient in soluble P-selectin (sP-sel), which is due to a defective binding interaction between PSGL-1 and P-sel, because mice lacking alpha(1,3)-fucosyltransferase-VII are also deficient in sP-sel...

BACKGROUND The relationship between lower urinary tract symptoms (LUTS) and common mental health disorders such as depression and anxiety in men remains unclear. Inflammation has recently been identified as an independent risk factor for LUTS and depression. This study aimed to assess the association between depression, anxiety and LUTS, and the moderating influence of systemic inflammation, in...

Mutations in either of two human presenilin genes (PS1 and PS2) cause Alzheimer's disease. Here we describe genetic and physical interactions between Caenorhabditis elegans SEL-10, a member of the Cdc4p family of proteins, and SEL-12, a C. elegans presenilin. We show that loss of sel-10 activity can suppress the egg-laying defective phenotype associated with reducing sel-12 activity, and that S...

Sex-determination in Caenorhabditis elegans requires regulation of gene transcription and protein activity and stability. sel-10 encodes a WD40-repeat-containing F-box protein that likely mediates the ubiquitin-mediated degradation of important sex-determination factors. Loss of sel-10 results in a mild masculinization of hermaphrodites, whereas dominant alleles of sel-10, such as sel-10(n1074)...

BACKGROUND A previous study reported a high prevalence of spinal epidural lipomatosis (SEL) in patients with Scheuermann kyphosis (SK) and suggested that it may play a role in the pathogenesis of this disease. According to our observation, however, SEL occurs in other spinal kyphotic deformities as well. The aim of this study was to test the hypothesis that SEL commonly occurs in patients with ...

Hermaphrodites carrying dominant mutations in the gene egl-41 (egl, egg-laying defective) lack the hermaphrodite-specific HSN neurons but have the male-specific CEM neurons and therefore are weakly masculinized (1, 2). Our analyses with a deficiency (nDf42) and a duplication (ctDp8) that span the egl-41 locus indicate that egl-41 is not haplo-insufficient and that the dominant mutations cause a...

The attitude towards computer-related tasks, computer anxiety, and spatial visualization ability (SVA) of a group of first-year computer science students were measured just before their study commenced. The results were analyzed empirically based on two independent variables, i.e., culture and computer experience. It was found that African and European users generally have the same attitude tow...

results the single covariance analysis of ancova indicated that the value of eta about 72% of variance of anxiety variable and about 76% of variance of drug abuse variable are taken in to account for variable of group. the intervention was effective in reducing anxiety and attitude to crack in males. evaluating the adjusted mean showed the effectiveness of matrix method on anxiety and attitude ...