Chang H-W, Wu V-C, Huang C-Y, Huang H-Y, Chen Y-M, Chu T-S, Wu K-D, Hsieh B-S. D4 dopamine receptor enhances angiotensin II-stimulated aldosterone secretion through PKC-ε and calcium signaling. Am J Physiol Endocrinol Metab 294: E622–E629, 2008. First published January 2, 2008; doi:10.1152/ajpendo.00657.2007.—Aldosterone secretion is subjected to dopaminergic regulation. Our previous study show...

We consider a one-dimensional variational problem arising in connection with model for cholesteric liquid crystals. The principal feature of our study is the assumption that twist deformation nematic director incurs much higher energy penalty than other modes deformation. appropriate ratio elastic constants then gives small parameter ε entering an Allen-Cahn-type functional augmented by term. b...

In this paper ε-MDP-models are introduced and convergence theorems are proven using the generalized MDP framework of Szepesvári and Littman. Using this model family, we show that Q-learning is capable of finding near-optimal policies in varying environments. The potential of this new family of MDP models is illustrated via a reinforcement learning algorithm called event-learning which separates...

a f(x) dx (which one would use for instance to compute the work required to move a particle from a to b). For simplicity we shall restrict attention here to functions f : R → R which are continuous on the entire real line (and similarly, when we come to differential forms, we shall only discuss forms which are continuous on the entire domain). We shall also informally use terminology such as “i...

This paper investigates the following natural greedy procedure for clustering in the bi-criterion setting: iteratively grow a set of centers, in each round adding the center from a candidate set that maximally decreases clustering cost. In the case of k-medians and k-means, the key results are as follows. • When the method considers all data points as candidate centers, then selecting O(k log(1...

Addressing an integrated decision-making structure for planting and harvesting scheduling may lead to more realistic, accurate, and efficient decision in fresh product supply chain. This study aims to develop an integrated bi-objective tactical and operational planning model for producing and distributing fresh crops. The first objective of the model is to maximize total revenue of supply chain...

In this paper, a bi-objective mixed-integer linear optimization model for Closed-loop Supply Chain Network Design Problem (CLSCND) is developed. The proposed model includes both the forward and reverse directions and includes different types of facilities, namely, manufacturing/remanufacturing centers, warehouses, and disassembly centers. The first objective function tried to minimize the total...

The efficient management of nursing personnel is of vital importance in a hospital’s environment comprising a vast share of the hospital’s operational costs. In the nurse scheduling problem (NSP), the target is to allocate shifts to the nurses in order to satisfy the hospital’s demand during the planning horizon by considering different objective functions. This paper presents a multi-objective...

Hazardous waste management incorporates collection, separation, treatment, recycling and disposal of hazardous wastes. In this paper, a new multi-objective mixed integer model is presented for hazardous waste collection problem. The model aims to minimize transportation and construction costs, and environmental and population risks in hazardous waste management systems. This model is applied in...