Background and purpose: Anti-apoptotic protein Bcl-2 prevents apoptosis through the mitochondrial pathway and high-level expression of Bcl-2 is required for survival of chronic lymphocytic leukemia (CLL). Berberine (BBR) is an alkaloid that induces apoptosis of cancer cells via mitochondrial pathways. The aim of this study was to investigate the effect of Berberine on Bcl-2 gene expression in p...

Bcl-2, a well-known anti-apoptotic gene, promotes cell viability without cell proliferation. Expression of the bcl-2 oncogene is reported in certain low grade neoplasms including Basal Cell Carcinomas(BCCs). Bcl-2 expression in BCCs is contradictory, with 67-100% immunopositivity being reported. The purpose of this study was to evaluate bcl-2 expression in the indolent variants of B...

Background: Although some studies have studied the mechanism of action of beta cells in animal models and more or less in human populations, but so far the role of exercise therapy or exercise exercise HIIT with black grape supplementation on the expression of genes involved in pancreatic beta cells This study investigates the effect of black grape supplementation combined with intense intermit...

Background and Objective: Ghrelin has different functions in the body and one of its newly known roles is the antiapoptotic effect. However, this effect of ghrelin has not been considered in the probable hypoxia induced apoptosis in the animal lung tissue. The aim of this study was to examine the effect of ghrelin treatment on Bax/Bcl-2 gene expression in the lung tissue of rats with chronic hy...

Introduction: Regular exercise training with alternating volume fluctuatesblood glucous levels and by regulating signaling in gene expression reduces in myocardial cell apoptosis in diabetic patients. The purpose of this study was the effect of 8 weeks of high intensity interval training on the gene expression of BAX and BCL-2 in the left ventricle of diabetic rats. Methods: The present study ...