background: whispering gallery modes (wgm) biosensors are ultrasensitive systems that can measure amount of adsorbed layer onto the micro-cavity surface. they have many applications including protein, peptide growth, dna and bacteria detection, molecular properties measurements and specific interaction and drug table recognitions due to their high sensitivity, compact size and label free sensin...

Construction of highly efficient microbial cell factories producing drop-in biofuel alkanes is severely limited due to the lack of a fast detection method against alkanes. Here we first developed a sensitive fluorescent biosensor for rapid and in situ monitoring of intracellular alkane synthesis. Using GFP as reporter, the biosensor could actively respond to the intracellular alkane products, e...

ImmunoFET (IMFET) biosensor is a simple platform for the detection of biotinylated products of polymerase chain reaction (PCR). Construction of the IMFET biosensor started with adsorption of 1.5 mg/mL of protein A (PA) onto the insulated gate surface of ISFET for 90 min. Next, the immobilized 1/500 dilution of anti-biotin antibody was adsorbed onto the PA layer for 60 min. The IMFET biosensor w...

in this research, an enzyme modified electrode has been produced during the electropolymerization of aniline through incorporation of sulfite oxidase into a conducting polymer. then the bioelectrochemical response of resulted sulfite biosensor was investigated at different experimental conditions. study of  the stability of the resulted sulfite biosensor revealed that formation of a passive fil...

The enzymes immobilization of the is crucially effective factor in biosensor preparation. Metal nanoparticles potentially able to immobilize the enzymes according to unique properties including large surface-to-volume ratio, high surface reaction activity, high catalytic efficiency, and strong adsorption ability. A novel and highly sensitive amperometric glucose biosensor was obtained by using ...

the transformation of biochemical information into a physical or chemical signal is the basic idea behind a biosensor. the efficient detection of charged biomolecules by biosensor with appropriate device has caught tremendous research interest in the present decade. the present work is related to the simulation study of the performance of a functionalized surface of a biologically sensitive fie...

The present study investigates the angular response and sensitivity of a surface plasmon resonance biosensor with metamaterial, by taking the advantage of the remarkable property of metamaterials. The proposed biosensor numerically shows that silver with a metamaterial layer enhances the sensitivity. The thickness of metamaterial and silver layer has been optimized. On comparing these results w...

The response of a peroxidase-based optical biosensor was modelled digitally.A mathematical model of the optical biosensor is based on a system of non-linear reaction-diffusion equations. The modelling biosensor comprises two compartments, an enzyme layerand an outer diffusion layer. The digital simulation was carried out using finite differencetechnique. The influence of the substrate concentra...

BACKGROUND We have developed a silicon-based biosensor that generates a visual signal in response to nucleic acid targets. METHODS In this system, capture oligonucleotide probes are immobilized on the surface of the biosensor. Interaction of the capture probes with a complementary target and a biotinylated detector oligonucleotide allows initiation of formation of an organic thin film on the ...